Sekgranaticin, a SEK34b-Granaticin Hybrid Polyketide from Streptomyces sp. 166#
Sekgranaticin, a SEK34b-Granaticin Hybrid Polyketide from Streptomyces sp. 166#
复制标题
Sekgranaticin，一种来自链霉菌属的 SEK34b-Granaticin 杂合聚酮化合物。
DOI：
10.1021/acs.joc.9b01022
复制
发表时间：
2019-07-19
影响因子：
3.6
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
--
作者：
Lv, Qianqian;Fan, Yaqin;Zhu, Weiming
Sekgranaticin (1), a novel hybrid polyketide with a complex 6/6/6/6/6/6/6 7-ring system, was isolated together with granaticins A (2) and B (3) and methyl granaticinate (4) from the culture broth of Streptomyces sp. 166#. Its structure was elucidated by spectroscopic analysis. The absolute configuration was determined on the basis of the calculated C-13 NMR and electronic circular dichroism data. Compounds 1-4 exhibited potent cytotoxicity against cancer cell lines MCF-7, A549, P6C, and HCT-116 with IC50 values of 0.02-6.77 mu M. The biosynthetic pathway of sekgranaticin (1) was proposed.
