Right prefrontal TMS versus sham treatment of mania: a controlled study
Right prefrontal TMS versus sham treatment of mania: a controlled study
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DOI：
10.1034/j.1399-5618.2003.00003.x
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发表时间：
2003-02-01
影响因子：
5.4
通讯作者：
Grisaru, N
中科院分区：
文献类型：
--
作者：
Kaptsan, A;Yaroslavsky, Y;Grisaru, N
目的：据报道，左前额经颅磁刺激（TMS）在抑郁症中具有ECT样作用，因此我们计划在躁狂症中进行TMS研究。16名患者完成了右与左前额TMS的试验，20 Hz，2秒持续时间每列车，20列车，每天10个治疗日。躁狂症的评估使用躁狂量表，简明精神病评定量表和临床总体印象。在接受右前额经颅磁刺激治疗的患者中，观察到的改善显著高于接受左前额经颅磁刺激治疗的患者。我们现在报告的后续研究的权利，积极TMS与右假TMS具有相同的适应症和parameters.Methods：25例患者进入和19个完成的权利TMS与假的权利TMS。结果：右TMS是没有更有效的比假TMS。结论：这是可能的，以前的结果是由于左TMS恶化躁狂症的影响。或者，值得注意的是，本患者组比先前的TMS治疗躁狂症的研究有更多的精神病，抑郁症研究报告说，精神病是TMS反应的不良预后体征。
Objective: Left prefrontal transcranial magnetic stimulation (TMS) has been reported to have ECT-like effects in depression and we therefore planned a study of TMS in mania. Sixteen patients completed trial of right versus left prefrontal TMS at 20 Hz, 2-sec duration per train, 20 trains per day for 10 treatment days. Mania was evaluated using the Mania Scale, the Brief Psychiatric Rating Scale and the Clinical Global Impression. Significantly more improvement was observed in patients treated with right prefrontal TMS than with left prefrontal. We now report a follow-up study of right active TMS versus right sham TMS with the same indications and parameters.Methods: Twenty-five patients entered and 19 completed right TMS versus sham right TMS.Results: Right TMS was no more effective than sham TMS.Conclusions: It is possible that the previous results were due to an effect of left TMS to worsen mania. Alternatively, it is noted that the present patient group had much more psychosis than the previous study of TMS in mania, and depression studies have reported that psychosis is a poor prognostic sign for TMS response.