Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.
Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.
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DOI：
10.1038/hgv.2016.1
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发表时间：
2016
影响因子：
1.5
通讯作者：
Sasaki T
中科院分区：
文献类型：
--
作者：
Shimada-Sugimoto M;Otowa T;Miyagawa T;Khor SS;Omae Y;Toyo-Oka L;Sugaya N;Kawamura Y;Umekage T;Miyashita A;Kuwano R;Kaiya H;Kasai K;Tanii H;Okazaki Y;Tokunaga K;Sasaki T
我们在此报告了日本人群中 TMEM132D 与恐慌症 (PD) 之间的关联，评估了 HLA-DRB1*13:02 的影响，我们之前报道过 HLA-DRB1*13:02 作为 PD 的易感性遗传因素。 TMEM132D 中的 SNP 在没有 HLA-DRB1*13:02（rs4759997；P=5.02×10−6，比值比=1.50）的受试者中显示与 PD 显着相关，但在具有 HLA 等位基因的受试者中则不然。 TMEM132D 可能在没有 HLA-DRB1*13:02 的受试者的 PD 发展中发挥作用。
We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1*13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1*13:02 (rs4759997; P=5.02×10−6, odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*13:02.