Inhibition of β-Lactamase in Neisseria gonorrhoeae by Sodium Clavulanate
Inhibition of β-Lactamase in Neisseria gonorrhoeae by Sodium Clavulanate
复制标题
克拉维酸钠对淋病奈瑟菌β-内酰胺酶的抑制作用
DOI：
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发表时间：
1978
影响因子：
4.9
通讯作者：
C. Thornsberry
中科院分区：
文献类型：
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作者：
J. Miller;C. Baker;C. Thornsberry
亚抑菌浓度的克拉维酸钠影响青霉素G、氨苄西林或阿莫西林对β-内酰胺酶阳性淋病奈瑟菌菌株的活性，表现为药物对微生物的最小抑菌浓度显著降低。该化合物不影响这些青霉素对β-内酰胺酶阴性N.淋病对头孢西丁抗β-内酰胺酶阴性或阳性菌株的活性也没有影响。克拉维酸钠导致青霉素类对β-内酰胺酶阳性微生物的最小抑菌浓度降低，可能是由于该化合物对β-内酰胺酶的抑制作用。
Sodium clavulanate at subinhibitory concentrations affected the activity of penicillin G, ampicillin, or amoxicillin on β-lactamase-positive strains of Neisseria gonorrhoeae as demonstrated by marked reduction in the minimal inhibitory concentrations of the drugs for the organisms. The compound did not affect the activity of these penicillins on β-lactamase-negative strains of N. gonorrhoeae. It also had no effect on the activity of cefoxitin against either β-lactamase-negative or -positive strains. The reduction in minimal inhibitory concentrations of the penicillins for the β-lactamase-positive organisms brought about by sodium clavulanate is probably due to inhibition of the β-lactamase by the compound.