Synthesis of lipopolyhydroxylalkyleneamines for gene delivery.
Synthesis of lipopolyhydroxylalkyleneamines for gene delivery.
复制标题
用于基因传递的脂多羟基亚烷基胺的合成。
DOI：
10.1016/j.bmcl.2006.01.120
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Liu,Dexi
中科院分区：
文献类型：
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作者：
Li,Qun;Zhang,Guisheng;Marhefka,Joie;Kameneva,MarinaV;Liu,Dexi
Various bis(2-hydroxy-3-chloropropyl)alkylamines were synthesized by coupling primary amine with epichlorohydrin and utilized as a monomer to react with ethylenediamine (EDA), N,N′-dimethylethylenediamine (DMEDA), or tetramethylethylenediamine (TMEDA) to generate a series of lipopolyhydroxylalkyleneamines. The number- and weight-average molecular weight (Mnand Mw) and polydispersity index (Mw/Mn) of the lipopolyhydroxylalkyleneamines were dependent on reactant solvent and reaction temperature. The compounds with EDA as backbone have better transfection activity and lower toxicity than those with DMEDA and TMEDA as backbone.
