Association of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio With Diabetic Retinopathy.
Association of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio With Diabetic Retinopathy.
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单核细胞与高密度脂蛋白胆固醇比率与糖尿病视网膜病变的关联
DOI：
10.3389/fcvm.2021.707008
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发表时间：
2021
影响因子：
3.6
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Tang X;Tan Y;Yang Y;Li M;He X;Lu Y;Shi G;Zhu Y;Nie Y;Li H;Mu P;Chen Y
背景：2型糖尿病（T2 DM）的慢性炎症是糖尿病视网膜病变（DR）发展的重要因素。单核细胞与高密度脂蛋白胆固醇（HDL-C）比值（MHR）是一种与炎症和氧化应激状态相关的新的简单测量方法。然而，鲜为人知的是，关于MHR在评估DR的发展的作用。方法：共有771例T2 DM患者和607名健康对照者参加了这项横断面研究。进行MHR测定和眼部检查。分析T2 DM患者MHR与DR患病率的关系。结果：DR组MHR明显高于非DR组（P < 0.05）和健康对照组（P < 0.01）。不同DR严重程度的MHR差异无统计学意义。此外，非黄斑水肿患者和黄斑水肿患者的MHR相似。Logistic回归分析显示，MHR与糖尿病患者DR的发生独立相关[OR = 1.438，95% CI：1.249-1.655，P < 0.01]。通过HbA 1c水平和糖尿病病程进行分层后，MHR仍与DR的患病率独立相关。结论：我们的研究表明，MHR可作为T2 DM患者DR患病率的标志物。
Background: Chronic inflammation in type 2 diabetes mellitus (T2DM) is an essential contributor to the development of diabetic retinopathy (DR). The monocyte–to–high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel and simple measure related to inflammatory and oxidative stress status. However, little is known regarding the role of the MHR in evaluating the development of DR. Methods: A total of 771 patients with T2DM and 607 healthy controls were enrolled in this cross-sectional study. MHR determination and eye examination were performed. The association of MHR with the prevalence of DR in T2DM patients was analyzed. Results: The MHR in patients with DR was significantly higher than that in both non-DR diabetic patients (P < 0.05) and healthy controls (P < 0.01). No significance was observed in the MHR of different DR severity grades. Moreover, the MHR was similar between patients with non-macular oedema and those with macular oedema. Logistic regression analysis demonstrated that MHR was independently associated with the prevalence of DR in diabetic patients [odds ratio (OR) = 1.438, 95% confidence interval (CI): 1.249–1.655, P < 0.01]. After additional stratification by HbA1c level and diabetic duration, the MHR was still independently associated with the prevalence of DR. Conclusions: Our study suggests that the MHR can be used as a marker to indicate the prevalence of DR in patients with T2DM.