Concordance among three self-reported measures of medication adherence and pharmacy refill records
Concordance among three self-reported measures of medication adherence and pharmacy refill records
复制标题
DOI：
10.1331/1544345053623573
复制
发表时间：
2005-03-01
影响因子：
2.1
通讯作者：
Perri, Matthew, III
中科院分区：
文献类型：
--
作者：
Cook, Christopher L.;Wade, William E.;Perri, Matthew, III
目的：评估之前验证的三项自我报告的药物依从性测量和药房补充记录 (RR) 之间的一致性程度。设计：横断面研究。地点：佐治亚州东北部农村地区的五个初级保健医生办公地点。参与者：139 名患有以下一种或多种慢性疾病的成年患者：高血压、糖尿病、高胆固醇血症、甲状腺功能减退症或需要激素替代治疗的疾病。干预措施：研究参与者完成了简短的药物问卷调查(BMQ)、药物依从性调查 (MAS) 和医疗结果研究 (MOS) 工具；用于治疗目标疾病的一种或多种药物的药房 RR 是从研究参与者使用的药房获得的。主要结果指标：坚持目标疾病的药物治疗。结果：参与者几乎都是白人 (98.6%)，与进行研究的阿巴拉契亚地区一致，并且大多数是女性 (71.9%)。虽然 91.4% 的研究参与者报告大部分或全部时间都在服用研究药物，但 RR 显示糖尿病、高血压、甲状腺功能减退、高胆固醇血症和激素替代疗法的平均依从率分别为 82.6%、82.1%、79.1%、74.6% 和 69.8%。 RR 与 MAS、MOS 和 BMQ 信念筛选之间的中度相关性分别为 0.234、0.261 和 0.213。 Spearman 相关性范围为 RR 和 BMQ 方案子量表之间的 0.091 到 MOS 和 MAS 之间的 0.313。 Pearson 卡方检验表明，本研究中只有 BMQ 信念分量表显着。结论：由于在经过验证的依从性测量中发现弱到中度的一致性，因此在药房实践中选择有用的依从性测量很困难。这些发现强调了评估患者的服药行为以及评估和比较依从性研究结果的困难。需要制定有效且可靠的措施来轻松评估社区药房的用药依从行为。关键词：依从性、慢性病、糖尿病、高血压、高胆固醇血症、激素替代疗法、甲状腺功能减退症。
Objective: To evaluate the level of agreement among three previously validated self-reported medication adherence measures and pharmacy refill records (RRs).Design: Cross-sectional study.Setting: Five primary care physician office sites in rural northeast Georgia.Participants: 139 adult patients with one or more of these chronic diseases: hypertension, diabetes mellitus, hypercholesterolemia, hypothyroidism, or a condition requiring hormone replacement therapy.Interventions: Study participants completed the Brief Medication Questionnaire (BMQ), the Medication Adherence Survey (MAS), and the Medical Outcomes Study (MOS) instruments; pharmacy RRs for the medication or medications being used to treat the target disease were obtained from pharmacies used by the study participants.Main Outcome Measures: Adherence to medication therapy for target disease.Results: Participants were nearly all white (98.6%), consistent with the Appalachian area in which the study was conducted, and mostly women (71.9%). While 91.4% of study participants reported taking their study medication most or all of the time, RRs showed mean adherence rates of 82.6%, 82.1%, 79.1%, 74.6%, and 69.8% for diabetes mellitus, hypertension, hypothyroidism, hypercholesterolemia, and hormone replacement therapy, respectively. Moderate correlations of.234, .261, and .213 were found between RRs and the MAS, MOS, and BMQ belief screen, respectively. Spearman correlations ranged from .091 between RRs and the BMQ regimen subscale to .313 between MOS and MAS. Pearson chi-square tests showed that only the BMQ belief subscale was significant in this study.Conclusion: Because of the weak to moderate concordance found among validated measures of adherence, the selection of a useful adherence measure in pharmacy practice is difficult. These findings underscore the difficulty in both assessing patients' medication-taking behavior and assessing and comparing the results of adherence research. The development of valid and reliable measures for easily assessing medication adherence behavior in community pharmacies is needed. Keywords: Adherence, chronic disease, diabetes, hypertension, hypercholesterolemia, hormone replacement therapy, hypothyroidism.