Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: Comparison with dextrose and sucrose
Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: Comparison with dextrose and sucrose
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DOI：
10.1089/109662004322984789
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发表时间：
2004-03-01
影响因子：
2.4
通讯作者：
Al-Waili, NS
中科院分区：
文献类型：
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作者：
Al-Waili, NS
本研究包括以下实验：（1）葡萄糖溶液（250mL水，含75g葡萄糖）或蜂蜜溶液（250mL水，含75g天然蜂蜜）对血浆葡萄糖水平（PGL）、血浆胰岛素和血浆C肽的影响（8名受试者）； (2) 葡萄糖、蜂蜜或人造蜂蜜（250毫升水中含有35克葡萄糖和40克果糖）对胆固醇和甘油三酯（TG）的影响（9名受试者）； (3)服用15天的蜂蜜溶液对PGL、血脂、C反应蛋白(CRP)和同型半胱氨酸的影响(8名受试者)； (4)蜂蜜或人造蜂蜜对6名高胆固醇血症患者和5名高甘油三酯血症患者胆固醇和TG的影响； (5)蜂蜜15天对5例胆固醇、CRP升高患者血脂、CRP的影响； (6)70g葡萄糖或90g蜂蜜对7名2型糖尿病患者PGL的影响； (7)30g蔗糖或30g蜂蜜对5名糖尿病患者的PGL、血浆胰岛素和血浆C肽的影响。在健康受试者中，葡萄糖在 1 小时 (53%) 和 2 小时 (3%) 时升高 PGL，并在 3 小时后降低 PGL (20%)。蜂蜜在 1 小时后升高 PGL（14%），在 3 小时后降低（10%）。服用葡萄糖后胰岛素和 C 肽的升高明显高于服用蜂蜜后的胰岛素和 C 肽。葡萄糖在 1 小时后轻微降低胆固醇和低密度脂蛋白胆固醇 (LDL-C)，在 2 小时后显着降低，并在 1、2 和 3 小时后增加 TG。人造蜂蜜会略微降低胆固醇和低密度脂蛋白胆固醇，并升高甘油三酯。蜂蜜可降低胆固醇、低密度脂蛋白胆固醇和甘油三酯，并略微升高高密度脂蛋白胆固醇（HDL-C）。食用蜂蜜 15 天可降低胆固醇 (7%)、LDL-C (1%)、TG (2%)、CRP (7%)、同型半胱氨酸 (6%) 和 PGL (6%)，并增加 HDL-C (2%)。在高甘油三酯血症患者中，人造蜂蜜会增加甘油三酯，而蜂蜜则会降低甘油三酯。在高脂血症患者中，人造蜂蜜会增加 LDL-C，而蜂蜜会降低 LDL-C。 15 天后，蜂蜜可降低胆固醇 (8%)、LDL-C (11%) 和 CRP (75%)。在糖尿病患者中，与葡萄糖相比，蜂蜜引起的 PGL 升高显着降低。 30 分钟时，蜂蜜后 PGL 的升高高于蔗糖后，而在 60、120 和 180 分钟时，蜂蜜后 PGL 的升高低于蔗糖后。 30、120 和 180 分钟后，蜂蜜比蔗糖更能引起胰岛素升高。蜂蜜可降低正常人和高脂血症受试者的血脂、同型半胱氨酸和 CRP。与葡萄糖和蔗糖相比，蜂蜜导致糖尿病患者 PGL 升高较低。
This study included the following experiments: (1) effects of dextrose solution (250 mL of water containing 75 g of dextrose) or honey solution (250 mL of water containing 75 g of natural honey) on plasma glucose level (PGL), plasma insulin, and plasma C-peptide (eight subjects); (2) effects of dextrose, honey, or artificial honey (250 mL of water containing 35 g of dextrose and 40 g of fructose) on cholesterol and triglycerides (TG) (nine subjects); (3) effects of honey solution, administered for 15 days, on PGL, blood lipids, C-reactive protein (CRP), and homocysteine (eight subjects); (4) effects of honey or artificial honey on cholesterol and TG in six patients with hypercholesterolemia and five patients with hypertriglyceridemia; (5) effects of honey for 15 days on blood lipid and CRP in five patients with elevated cholesterol and CRP; (6) effects of 70 g of dextrose or 90 g of honey on PGL in seven patients with type 2 diabetes mellitus; and (7) effects of 30 g of sucrose or 30 g of honey on PGL, plasma insulin, and plasma C-peptide in five diabetic patients. In healthy subjects, dextrose elevated PGL at 1 (53%) and 2 (3%) hours, and decreased PGL after 3 hours (20%). Honey elevated PGL after 1 hour (14%) and decreased it after 3 hours (10%). Elevation of insulin and C-peptide was significantly higher after dextrose than after honey. Dextrose slightly reduced cholesterol and low-density lipoprotein-cholesterol (LDL-C) after 1 hour and significantly after 2 hours, and increased TG after 1, 2, and 3 hours. Artificial honey slightly decreased cholesterol and LDL-C and elevated TG. Honey reduced cholesterol, LDL-C, and TG and slightly elevated high-density lipoprotein-cholesterol (HDL-C). Honey consumed for 15 days decreased cholesterol (7%), LDL-C (1%), TG (2%), CRP (7%), homocysteine (6%), and PGL (6%), and increased HDL-C (2%). In patients with hypertriglyceridemia, artificial honey increased TG, while honey decreased TG. In patients with hyperlipidemia, artificial honey increased LDL-C, while honey decreased LDL-C. Honey decreased cholesterol (8%), LDL-C (11%), and CRP (75%) after 15 days. In diabetic patients, honey compared with dextrose caused a significantly lower rise of PGL. Elevation of PGL was greater after honey than after sucrose at 30 minutes, and was lower after honey than it was after sucrose at 60, 120, and 180 minutes. Honey caused greater elevation of insulin than sucrose did after 30, 120, and 180 minutes. Honey reduces blood lipids, homocysteine, and CRP in normal and hyperlipidemic subjects. Honey compared with dextrose and sucrose caused lower elevation of PGL in diabetics.