Evaporative cooling provides a major metabolic energy sink
Evaporative cooling provides a major metabolic energy sink
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DOI：
10.1016/j.molmet.2019.06.023
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发表时间：
2019-09-01
影响因子：
8.1
通讯作者：
Alexander, C. M.
中科院分区：
文献类型：
--
作者：
Kasza, Ildiko;Adler, Doug;Alexander, C. M.
目的：以热量的形式消除食物热量有助于纠正肥胖所表现出的代谢能量的过度积累。先前的研究主要集中在米色和棕色脂肪组织中诱导生热作为这一原理的应用，特别是因为与生热激活相关的β-肾上腺素能环境已被证明具有积极的健康影响。与此策略相反的是热损失的调节；我们认为，热量保存效率低下的哺乳动物将需要更多的生热作用来维持体温。方法：将表面温度热成像和经表皮失水率相结合，以分析基因工程和基因变异小鼠的总热传递。结果：将这些数据与能量消耗数据结合起来，生成生物物理概况，以测试蒸发冷却率增加的意义。结论：我们表明，无论是由于自然发生的变异（SKH-1），小鼠皮肤的保热性能差异很大小鼠），或对保温脂质层进行基因改造（SCD1、DGAT1 或 Agouti Ay 肥胖小鼠）。特别是，我们将注意力转向由于经表皮失水而导致的蒸发冷却速率差异很大。蒸发冷却造成的热损失率较高，导致生热需求增加。我们推测，可以利用这种生理学来创建能量汇，以协助旨在治疗代谢疾病的策略。 (C) 2019 年作者。由爱思唯尔有限公司出版。
Objective: Elimination of food calories as heat could help redress the excess accumulation of metabolic energy exhibited as obesity. Prior studies have focused on the induction of thermogenesis in beige and brown adipose tissues as the application of this principle, particularly because the beta-adrenergic environment associated with thermogenic activation has been shown to have positive health implications. The counterpoint to this strategy is the regulation of heat loss; we propose that mammals with inefficient heat conservation will require more thermogenesis to maintain body temperature.Methods: Surface temperature thermography and rates of trans-epidermal water loss were integrated to profile the total heat transfer of genetically-engineered and genetically variable mice.Results: These data were incorporated with energy expenditure data to generate a biophysical profile to test the significance of increased rates of evaporative cooling.Conclusions: We show that mouse skins vary considerably in their heat retention properties, whether because of naturally occurring variation (SKH-1 mice), or genetic modification of the heat-retaining lipid lamellae (SCD1, DGAT1 or Agouti Ay obese mice). In particular, we turn attention to widely different rates of evaporative cooling as the result of trans-epidermal water loss; higher rates of heat loss by evaporative cooling leads to increased demand for thermogenesis. We speculate that this physiology could be harnessed to create an energy sink to assist with strategies aimed at treating metabolic diseases. (C) 2019 The Authors. Published by Elsevier GmbH.