Assembly of the cricket cercal sensory system: genetic and epigenetic control.
Assembly of the cricket cercal sensory system: genetic and epigenetic control.
复制标题
蟋蟀尾部感觉系统的组装：遗传和表观遗传控制。
DOI：
10.1002/neu.480210109
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Chiba,A
中科院分区：
文献类型：
--
作者：
Murphey,RK;Chiba,A
为了更好地理解感觉系统的组装，板球的颈部感觉系统正在使用解剖学、生理学和计算机模拟技术进行检查。这种特殊的感觉系统之所以引起人们的兴趣，是因为它的功能类似于数字上更复杂的脊椎动物感觉系统，但对神经科学家来说，它提供了少量大型已识别神经元的技术优势。在这个系统中，我们研究了感觉处理的两个方面；刺激的空间方面告诉动物目标在环境中的位置，刺激的质量帮助动物识别刺激。刺激的空间方面是通过动物感觉环境的地形图来分析的。刺激其他方面的特征提取机制缺乏明显的解剖顺序，而是嵌入在地形图中。我们正试图梳理出这个感觉系统组装过程中的遗传和表观遗传成分。在这里，我们回顾了我们的进展，重点是其组装的表观遗传方面。我们描述了先前发表的关于可塑性的工作以及新的实验，这些实验集中在神经元活动在神经回路组装中的作用。最后，我们简要地描述了模拟实验，这些实验有助于我们理解各种形式的突触可塑性在决定接受野中的作用。
The cercal sensory system of the cricket is being examined using anatomical, physiological, and computer simulation techniques in order to better understand the assembly of sensory systems. This particular sensory system is of interest because it functions like numerically more complex vertebrate sensory systems but offers, to the neuroscientist, the technical advantages of a small number of large identified neurons. Two aspects of sensory processing are being examined in this system; the spatial aspects of a stimulus that tell an animal where a target is in its environment, and the qualities of a stimulus that help the animal to identify the stimulus. The spatial aspects of a stimulus are analyzed by a topographic mapping of the animal's sensory environment. The feature extraction machinery for other aspects of the stimulus lacks any obvious anatomical order and is embedded within the topographic map. We are attempting to tease apart the genetic and the epigenetic components of the assembly process for this sensory system. Here we review our progress with emphasis on the epigenetic aspects of its assembly. We describe previously published work on plasticity as well as new experiments focussed on the role of neuronal activity in the assembly of this neural circuit. Finally, we briefly describe simulation experiments that are helping us understand the role of various forms of synaptic plasticity in the determination of receptive fields.