Water-soluble NaYF4:Yb/Erupconversion nanophosphors: Synthesis, characteristics and application in bioimaging
Water-soluble NaYF4:Yb/Erupconversion nanophosphors: Synthesis, characteristics and application in bioimaging
复制标题
水溶性NaYF4:Yb/Erupconversion纳米荧光粉：合成、特性及其在生物成像中的应用
DOI：
10.1016/j.inoche.2009.12.031
复制
发表时间：
2010-03-01
影响因子：
3.8
通讯作者：
Li, Fuyou
中科院分区：
文献类型：
--
作者：
Cao, Tianye;Yang, Tianshe;Li, Fuyou
采用二甘醇（DEG）为溶剂，在高温下对油酸封端的疏水性稀土上转换纳米荧光粉（UCNPs）进行表面配体交换，制备了水溶性柠檬酸盐（cit）包覆的稀土上转换纳米荧光粉（UCNPs）。TEM和XRD等表征结果表明，配体交换反应对UCNPs的形貌和结晶度等化学性质没有明显影响。当用980 nm近红外（NIR）光激发UCNP标记的细胞时，观察到明亮的UC发光，证明Cit-UCNP可用作HeLa细胞成像的非特异性标记。这些结果表明Cit-UCNP是用作生物成像探针的有希望的候选物（C）2010 Elsevier B VAll rights reserved。
Water-soluble and citrate (cit) coated rare-earth upconversion nanophosphors (UCNPs) were prepared by an efficient Surface ligand exchange of the oleic acid capped hydrophobic UCNPs in diethylene glycol (DEG) at high temperature The successful surface ligand exchange of the UCNPs with citrate was confirmed by Fourier-transform infrared (FTIR) spectroscopy Further characterizations such as TEM and XRD showed that the ligand exchange reaction had no obvious influence on chemical properties of UCNPs, Such as morphology and crystallization Furthermore, bright UC luminescence was observed when UCNPs-labeled cells were excited with 980nm near-infrared (NIR) light proving that Cit-UCNPs can be used as non-specific labels for imaging HeLa cells These results indicate that the Cit-UCNPs are a promising candidate for use as bioimaging probes (C) 2010 Elsevier B V All rights reserved.