Complement component C1q as potential diagnostic but not predictive marker of preeclampsia
Complement component C1q as potential diagnostic but not predictive marker of preeclampsia
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DOI：
10.1111/aji.12586
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发表时间：
2016-12-01
影响因子：
3.6
通讯作者：
Bulla, Roberta
中科院分区：
文献类型：
--
作者：
Agostinis, ChIAra;Stampalija, Tamara;Bulla, Roberta
问题我们之前发现C1q由蜕膜的侵袭滋养层和内皮细胞组成型表达，并有助于血管和组织重塑。基于这些发现，我们试图确定 C1q 循环水平是否发生变化，可用作先兆子痫的诊断和预测标志物。研究方法我们测量了来自不同队列的正常孕妇和先兆子痫患者血清或血浆中 C1q、C4 和补体激活产物的水平。结果我们观察到，与匹配的健康孕妇相比，先兆子痫患者中 C1q 浓度显着降低，且与 C4 水平降低相关，但循环中 C1q 浓度没有显着差异。激活产物 C5a 和可溶性末端补体复合物 sC5b-9 的水平。对后来发展为先兆子痫的妇女在妊娠早期收集的血清样本的分析未能显示 C1q 水平下降。结论本研究结果表明，C1q 和 C4 水平低与先兆子痫相关，但不能用作预测标志物。
ProblemWe have previously found that C1q is constitutively expressed by invading trophoblast and endothelial cells of decidua and contributes to vascular and tissue remodeling. Based on these findings, we sought to determine whether there were changes in the circulating level of C1q that may be used as a diagnostic and predictive marker of preeclampsia.Method of StudyWe measured the levels of C1q, C4, and complement activation products in serum or plasma of normal pregnant women and preeclamptic patients from different cohorts.ResultsWe observed a marked decrease in the concentration of C1q associated with a reduced level of C4 in preeclamptic patients as compared to matched healthy pregnant woman but no significant difference in the circulating level of the activating products C5a and the soluble terminal complement complex sC5b-9. Analysis of serum samples collected at early phase of pregnancy from women who later developed preeclampsia failed to show a decrease in C1q level.ConclusionThe results of the present investigation demonstrate that low levels of C1q and C4 are associated with preeclampsia but cannot be used as predictive markers.