PECAM-1 (CD31) CLONING AND RELATION TO ADHESION MOLECULES OF THE IMMUNOGLOBULIN GENE SUPERFAMILY
PECAM-1 (CD31) CLONING AND RELATION TO ADHESION MOLECULES OF THE IMMUNOGLOBULIN GENE SUPERFAMILY
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DOI：
10.1126/science.1690453
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发表时间：
1990-03-09
期刊：
影响因子：
56.9
通讯作者：
MULLER, WA
中科院分区：
文献类型：
--
作者：
NEWMAN, PJ;BERNDT, MC;MULLER, WA
血小板膜糖蛋白的抗体被发现与以前确定的CD31骨髓单核细胞分化抗原和hec7，内皮细胞蛋白，是丰富的细胞间连接处的交叉反应。该抗体从内皮细胞文库鉴定互补DNA克隆。130千道尔顿的翻译序列包含6个细胞外免疫球蛋白（IG）样结构域，与IG超家族的细胞粘附分子（CAM）亚组最相似。这是血小板上唯一已知的CAM家族成员。其细胞表面分布表明参与细胞识别事件。
An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup of the Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.