P-cadherin-mediated Rho GTPase regulation during collective cell migration.
P-cadherin-mediated Rho GTPase regulation during collective cell migration.
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DOI：
10.1080/21541248.2016.1173772
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发表时间：
2016-07-02
期刊：
影响因子：
--
通讯作者：
Gauthier-Rouvière C
中科院分区：
文献类型：
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作者：
Plutoni C;Bazellières E;Gauthier-Rouvière C
This commentary addresses the role of P-cadherin in collective cell migration (CCM), a cooperative and coordinated migration mode, used by cells during normal and pathological migration processes. We discuss how cadherin-mediated cell-cell junctions (CCJs) play a critical role in CCM through their ability to regulate Rho GTPase-dependent pathways and how this leads to the generation and orientation of mechanical forces. We will also highlight the key function of P-cadherin (a poor prognostic marker in several tumors) in promoting collective cell movement in epithelial and mesenchymal cells.
