DISTRIBUTION AND SYNAPTIC CONTACTS OF THE CORTICAL TERMINALS ARISING FROM NEURONS IN THE RAT VENTROMEDIAL THALAMIC NUCLEUS
DISTRIBUTION AND SYNAPTIC CONTACTS OF THE CORTICAL TERMINALS ARISING FROM NEURONS IN THE RAT VENTROMEDIAL THALAMIC NUCLEUS
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DOI：
10.1016/0306-4522(90)90373-c
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发表时间：
1990-01-01
期刊：
影响因子：
3.3
通讯作者：
WRIGHT, AK
中科院分区：
文献类型：
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作者：
ARBUTHNOTT, GW;MACLEOD, NK;WRIGHT, AK
注射顺行示踪剂Phaseolus vulgaris-leucoagglutinin在丘脑腹内侧核内导致许多填充纤维在大鼠大脑皮层的额叶区。的纤维被限制在I层的上部，除了在一个小区域的运动皮层终端也被发现在更深的层。终末也见于纹状体，中脑网状结构的部分，偶尔在对侧腹内侧核。有一些地形顺序的投影与内侧和背侧区以及代表在内侧皮质，而腹内侧核的外侧部分更直接相关的皮质区，接受丘脑腹外侧核的投影。电子显微镜检查显示，在第一层的皮质终端突触接触树突棘和小树突的个人资料，表现出非常密集的突触后专业化。腹内侧核中的神经元可以从电极位置沿沿着皮质条逆向驱动，这不容易与皮质中任何已知的组织模式相关。只有一个刺激部位的丘脑神经元逆向反应时，更常见的刺激是在运动皮质区，这表明在这个地区的一个更受限制的终止模式是规则。
Injections of the anterograde tracer Phaseolus vulgaris-leucoagglutinin within the ventromedial thalamic nucleus resulted in many filled fibres in the frontal areas of rat cerebral cortex. The fibres were restricted to the upper part of layer I except in a small area of motor cortex where terminals were also found in deeper layers. Terminals were also seen in the striatum, in parts of the mesencephalic reticular formation and occasionally in the contralateral ventromedial nucleus. There is some topographical order in the projection with medial and dorsal areas well represented in medial cortex while lateral parts of ventromedial nucleus are more directly related to the cortical area that receives the ventrolateral thalamic nucleus projection. Electron microscopic examination showed the terminals in layer I of cortex making synaptic contact with dendritic spines and small dendritic profiles that showed a very dense postsynaptic specialization. Neurons in the ventromedial nucleus could be antidromically driven from electrode positions along strips of cortex which could not be easily related to any known organizational pattern in the cortex. Thalamic neurons responding antidromically to only one stimulation site were more common when the stimulation was within motor cortical areas, suggesting that in this region a more restricted pattern of termination is the rule.