Young and old subjects matched for aerobic capacity have similar noradrenergic responses to exercise.
Young and old subjects matched for aerobic capacity have similar noradrenergic responses to exercise.
复制标题
有氧能力匹配的年轻和年老受试者对运动的去甲肾上腺素能反应相似。
DOI：
10.1152/jappl.1993.74.1.49
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Murthy,VS
中科院分区：
文献类型：
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作者：
Kastello,GM;Sothmann,MS;Murthy,VS
已证明，在休息时和亚极量运动期间，循环去甲肾上腺素所指示的交感神经系统活动都会随着实际年龄的增长而增加。许多早期研究这种衰老现象的工作都使用了一个年轻的组，该组的峰值耗氧量（VO 2）高于老年组，这使得比较变得困难。在本研究中，年轻[n = 7，36 +/- 1.0（SE）岁]和老年受试者（n = 8，61 +/- 1.2岁）在峰值VO 2上匹配，然后在大约相同的相对次最大VO 2（75%）和功率输出下在自行车测力计上运动21分钟。最后一分钟通过肘前静脉留置导管进行21分钟的锻炼。年轻组和老年组的去甲肾上腺素反应分别如下：休息时，486 +/- 111对673 +/- 108; 7分钟，1，258 +/- 255对1，185 +/- 172; 14分钟，1，639 +/- 316对1，528 +/- 288;和21分钟，2，038 +/- 488 vs. 1，936 +/- 453 pg/ml。在任何时间段，这些反应在组间均无显著差异。各年龄组的肾上腺素值无统计学差异：静息，115 +/- 60 vs 88 +/- 51; 7 min，140 +/- 18 vs 326 +/- 88; 14 min，216 +/- 33 vs 366 +/- 104; 21 min，324 +/- 100 vs 447 +/- 113 pg/ml。（250字处删节）
Sympathetic nervous system activity as indicated by circulating norepinephrine has been demonstrated to increase with advancing chronological age both at rest and during submaximal exercise. Much of the earlier work investigating this aging phenomenon used a younger group that had a higher peak oxygen consumption (VO2) than did the older group, which made comparisons difficult. In the present study, young [n = 7, 36 +/- 1.0 (SE) yr] and old subjects (n = 8, 61 +/- 1.2 yr) were matched on peak VO2 and then exercised at approximately the same relative submaximal VO2 (75%) and power output on a cycle ergometer for 21 min. Blood samples were collected at rest and in the 7th, 14th, and last minute of a 21-min exercise bout via an indwelling catheter in an antecubital vein. The norepinephrine responses for the young and old groups, respectively, were as follows: rest, 486 +/- 111 vs. 673 +/- 108; 7 min, 1,258 +/- 255 vs. 1,185 +/- 172; 14 min, 1,639 +/- 316 vs. 1,528 +/- 288; and 21 min, 2,038 +/- 488 vs. 1,936 +/- 453 pg/ml. These responses were not significantly different between the groups at any time period. The epinephrine values for the age groups were not statistically different: rest, 115 +/- 60 vs 88 +/- 51; 7 min, 140 +/- 18 vs. 326 +/- 88; 14 min, 216 +/- 33 vs. 366 +/- 104; and 21 min, 324 +/- 100 vs. 447 +/- 113 pg/ml.(ABSTRACT TRUNCATED AT 250 WORDS)