Modified Beer's Law - historical perspectives and relevance in near-infrared monitoring of optical properties of human tissue
Modified Beer's Law - historical perspectives and relevance in near-infrared monitoring of optical properties of human tissue
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DOI：
10.1016/j.ergon.2009.02.011
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发表时间：
2010-03-01
影响因子：
3.1
通讯作者：
Maikala, Rammohan V.
中科院分区：
文献类型：
--
作者：
Maikala, Rammohan V.
研究光与人体组织的相互作用对于理解组织的功能变化和氧化代谢（例如，骨骼肌、脑）。这份手稿的重点是发展的光能定量吸收定律，从布格定律的成立比耳定律，以获得目前的应用前景的吸收概念，在调查的光学性质的光吸收发色团的人体组织。虽然这些吸收定律适用于确定固体或溶剂中存在的物质的绝对浓度，但这些定律没有考虑入射光的反射或散射，这导致了透射光强度的损失。强调了在700-1300 nm的近红外窗口中的光能量的重要性，与用于确定体内光学组织特性的电磁谱中的其他区域相比。由于人体组织是一种高度散射的非均匀介质，比尔定律在研究人体组织发色团方面的局限性。最后，修正的比尔定律，以调查在医学光谱窗口（700-900 nm）内的人体tissue.Relevance的光吸收发色团的浓度和吸光度的变化之间的关系进行了讨论：随着光传播通过人体组织，浓度的一些发色团在医学光谱窗口内随时间变化，这意味着在组织的生理变化。在过去的二十年中，这种光学原理在人体组织的健康和疾病的生物医学（非侵入性）研究中的应用有所增加。虽然在临床应用中令人印象深刻，但人体工程学和人为因素领域的研究人员在利用与工作场所人类表现相关的组织光学特性的潜力方面进展缓慢。(c)2009爱思唯尔有限公司版权所有。
Studying the interaction of light with human tissue is important in understanding functional changes and oxidative metabolism of tissue (e.g.. skeletal muscle, brain). This manuscript focuses on the development of quantitative absorption laws of light energy, from the inception of Bouguer Law to Beer's Law, to gain a perspective on the present application of the absorption concepts in investigating optical properties of light absorbing chromophores of human tissue. Although these absorption laws are applicable to determine the absolute concentration of substances present in solids or solvents, these laws do not take into consideration of either reflection or scattering of incident light that accounts for the loss of transmitted light intensity. Importance of light energy in the near-infrared window of 700-1300 nm compared to that of other regions in the electromagnetic spectrum for determination of optical tissue properties in vivo is emphasized. Since human tissue is a highly scattering non-homogenous medium, limitations of Beer's Law with respect to studying human tissue chromophores are presented. Finally, modifications of Beer's Law to investigate the relationship between changes in absorbency and concentrations of light absorbing chromophores within the medical spectral window (700-900 nm) in human tissue are discussed.Relevance to industry: As light propagates through human tissue, concentration of some chromophores varies in time within the medical spectral window, implying physiological changes in the tissue. Utilization of this optical principle in biomedical (non-invasive) research of the health and disease of human tissue has increased in the last two decades. While impressive in clinical applications, researchers in the field of ergonomics and human factors have been slow in exploiting the potential of examining optical properties of tissue relevant to human performance at the workplace. (c) 2009 Elsevier B.V. All rights reserved.