Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy.
Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy.
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DOI：
10.3233/jad-170350
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Ersland L
中科院分区：
文献类型：
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作者：
Mandal PK;Shukla D;Govind V;Boulard Y;Ersland L
谷胱甘肽（GSH）是人体内主要的抗氧化剂，参与活性自由基和过氧化物的解毒。GSH的分子结构构象取决于周围的微环境，它已被实验评估使用NMR和拉曼光谱技术，以及通过分子动力学模拟研究。聚合报告表明，GSH主要以两种主要构象存在，即，“伸展”和“折叠”。的NMR衍生的GSH构象的信息是必不可少的，以获得最佳的采集参数，在体内MRS实验针对GSH检测。为了进一步研究GSH构象异构体在体内MRS研究中的意义及其在健康和病理条件下的相对比例，需要采用通用方案进行GSH检测和定量的多中心临床研究。
Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., “extended” and “folded”. The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in in vivo MRS experiments targeted for GSH detection. To further investigate the implications of GSH conformers in in vivo MRS studies and their relative proportions in healthy and pathological conditions, a multi-center clinical research study is necessary with a common protocol for GSH detection and quantification.