T-helper 17 cytokines (interleukins 17, 21, 22, and 6, and tumor necrosis factor-) in patients with alopecia areata: association with clinical type and severity
T-helper 17 cytokines (interleukins 17, 21, 22, and 6, and tumor necrosis factor-) in patients with alopecia areata: association with clinical type and severity
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DOI：
10.1111/ijd.12808
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发表时间：
2016-06-01
影响因子：
3.6
通讯作者：
Bayoumy, Nervana M.
中科院分区：
文献类型：
--
作者：
Atwa, Mona A.;Youssef, Nahed;Bayoumy, Nervana M.
斑秃(Alopecia areata，AA)是一种以T细胞浸润和细胞因子产生为特征的器官特异性自身免疫性疾病。T辅助细胞17(Th17)在自身免疫性疾病的发病机制中起着至关重要的作用。对47例再障患者和40例健康体检者血清IL-17、IL-21、IL-22、IL-6和肿瘤坏死因子-α(TNF-α)水平进行检测，并探讨其与AA临床类型和病情严重程度的关系。结果AA患者血清IL-17、IL-21、IL-22、IL-6、肿瘤坏死因子-α水平均显著高于正常对照组(分别为：IL-17 33.2311.58vs.4.62+/-1.88pg/ml；P=0.000，IL-2162.10+/-6.11vs.48.38+/-3.31pg/ml；P=0.000，IL-2219.27+/-3.36vs.7.09+/-1.62pg/ml；P=0.000，IL-617.18+/-3.08vs.4.59+/-1.66pg/ml；P=0.000，TF19.94+/-3.59vs.9.95+/-2.42pg/ml；P=0.000)。血清IL-17、TNF-α水平与病情严重程度呈显著正相关。血清IL-22水平与AA病程呈显著正相关。结论AA患者血清中Th17细胞因子水平升高，提示这些细胞因子在这一重要皮肤病的发病机制中起重要作用。这也可能为再生障碍性贫血的新治疗策略提供理论基础。
BackgroundAlopecia areata (AA) is an organ-specific autoimmune disease characterized by T-cell infiltrates and cytokine production. T-helper 17 (Th17) cells are crucially involved in the pathogenesis of autoimmune diseases.ObjectivesOur aim was to assess the association of Th17 with AA. We examined interleukin (IL)-17, IL-21, IL-22, IL-6, and tumor necrosis factor-alpha (TNF-) levels in the serum of patients with AA and studied their association with clinical type and severity of AA.Subjects and methodsThe serum concentrations of IL-17, IL-21, IL-22, IL-6, and TNF- were measured in 47 patients with AA and 40 healthy controls. The clinical type of AA was determined, and the severity of hair loss was assessed in accordance with the Alopecia Areata Investigational Assessment Guideline criteria.ResultsThe serum concentrations of IL-17, IL-21, IL-22, IL-6, and TNF- were significantly higher in patients with AA as compared with healthy controls (mean: IL-17 33.2311.58 vs. 4.62 +/- 1.88pg/ml; P=0.000, IL-21 62.10 +/- 6.11 vs. 48.38 +/- 3.31pg/ml; P=0.000, IL-22 19.27 +/- 3.36 vs. 7.09 +/- 1.62pg/ml; P=0.000, IL-6 17.18 +/- 3.08 vs. 4.59 +/- 1.66pg/ml; P=0.000, TNF- 19.94 +/- 3.59 vs. 9.95 +/- 2.42pg/ml; P=0.000, respectively). There were significant positive correlations between serum IL-17, TNF-, and disease severity. There was also significant positive correlation between serum IL-22 and duration of AA.ConclusionOur results showed high serum levels of Th17 cytokines among patients with AA that may suggest a functional role of these cytokines in the pathogenesis of this important skin disease. It could also provide the rationale for new treatment strategies in AA.