Change of genetic determinants of left ventricular structure in adolescence: Longitudinal evidence from the Georgia Cardiovascular Twin Study
Change of genetic determinants of left ventricular structure in adolescence: Longitudinal evidence from the Georgia Cardiovascular Twin Study
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DOI：
10.1038/ajh.2008.178
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发表时间：
2008-07-01
影响因子：
3.2
通讯作者：
Snieder, Harold
中科院分区：
文献类型：
--
作者：
Kapuku, Gaston K.;Ge, Dongliang;Snieder, Harold
遗传对左心室（LV）结构的贡献是公认的，但这种影响是否以及如何因种族或年龄而异尚不清楚。METHODS参与者是517欧洲-美国（EA）和非洲-美国（AA）双胞胎对（平均年龄：14.6 +/- 3.0）在访问1和422 EA和AA双胞胎对在后续4.1年后。在两次访视时获得超声心动图。使用结构方程建模软件Mx分析数据。在第1次和第2次访视时，体重指数（BMI）是所有LV指标的强预测因子，占总方差的3.5-24.2%。血流动力学解释了高达4.5%的额外LV测量变异。在调整BMI后，LV测量结果显示出显著的遗传性（范围：21- 71%）。最佳拟合纵向模型显示，室间隔、后壁和相对壁厚（RWT）（但不是LV内径）具有相当大的新遗传效应，占第2次访视时表型方差的32-41%，无显著性别和种族效应。AAs患者左室质量指数存在性别差异（P < 0.01），男性受新遗传效应的影响显著（47%），而女性则无明显影响。没有性别差异被认为是在EA，与34%的表型方差在访问2归因于新的遗传effects.CONCLUSIONSThe心脏结构和几何形状的遗传性同样是实质性的在两个AA和EA。在AA女性中，除LV内径和LV质量指数外，所有指标均检测到显著的新遗传影响。进一步的发育遗传学研究是必要的，以阐明从青春期到成年期的过渡过程中出现的基因效应的性质。
BACKGROUNDGenetic contribution to left ventricular (LV) structure is generally recognized, but whether and how this influence varies by ethnicity or with age is unknown.METHODSParticipants were 517 European-American (EA) and African-American (AA) twin pairs (mean age: 14.6 +/- 3.0) at visit 1 and 422 EA and AA twin pairs at follow-up 4.1 years later. Echocardiograms were obtained on both visits. Data were analyzed using the structural equation modeling software Mx.RESULTSBody mass index (BMI) was a strong predictor for all LV measures at both visits 1 and 2, accounting for 3.5-24.2% of the total variance. Hemodynamics explained up to 4.5% additional LV measures variance. After adjusting for BMI, LV measures showed substantial heritability (range: 21-71 %). Best-fitting longitudinal models revealed considerable novel genetic effects on the interventricular septum, posterior wall-, and relative wall thickness (RWT) (but not LV internal diameter), accounting for 32-41% of the phenotypic variance at visit 2, with no significant gender and ethnic effects. There was a gender difference for LV mass index in AAs (P < 0.01), with a significant influence of novel genetic effects in males (47%), but not in females. No gender difference was seen in EAs, with 34% of the phenotypic variance at visit 2 attributable to novel genetic effects.CONCLUSIONSThe heritability of cardiac structure and geometry was equally substantial in both AAs and EAs. Significant novel genetic influences were detected for all measures but LV inner diameter and LV mass index in AA females. Further developmental genetic studies are warranted to elucidate the nature of the emerging gene effects during the transition from adolescence to adulthood.