Diverging Signal Transduction Pathways Activated by Interleukin 8 (IL-8) and Related Chemokines in Human Neutrophils
Diverging Signal Transduction Pathways Activated by Interleukin 8 (IL-8) and Related Chemokines in Human Neutrophils
复制标题
人中性粒细胞中白细胞介素 8 (IL-8) 和相关趋化因子激活的不同信号转导途径
DOI：
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发表时间：
1996
影响因子：
4.8
通讯作者：
P. Naccache
中科院分区：
文献类型：
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作者：
B. Damaj;S. McColl;K. Neote;C. Hébert;P. Naccache
Interleukin 8 (IL-8) and Gro-α are members of the CXC branch of a family of cytokines recently designated the “chemokine” superfamily. Recent evidence indicates that, contrary to previously held beliefs, IL-8 and Gro-α may not be perceived equivalently by neutrophils. In this study, we have evaluated the effects of IL-8 and Gro-α on the rate of calcium influx in human neutrophils and in 293 cells transfected with type A or type B IL-8 receptors. Of these two chemokines, only Gro-α induced an influx of calcium in neutrophils as judged by the sensitivity of the mobilization of calcium to the extracellular calcium chelator EGTA and to the nonselective divalent cation channel inhibitor SK&F 96365, as well as by manganese quenching experiments. IL-8 was similarly without effect on the rate of Mn2+ influx in 293 cells transfected with IL-8 receptor A (IL-8RA) or IL-8RB. On the other hand, Gro-α induced an SK&F 96365-sensitive increase of the rate of Mn+2 influx in IL-8RB-, but not in IL-8RA-transfected 293 cells. These results indicate not only that neutrophils respond differently to IL-8 than they do to Gro-α but, furthermore, that the consequences of the binding of IL-8 and Gro-α to IL-8RB are distinct.
趋化细胞因子的免疫病理学：白细胞介素 8 和单核细胞趋化蛋白 1 的作用。
DOI：
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发表时间：
1994
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Strieter,RM;Koch,AE;Antony,VB;FickJr,RB;Standiford,TJ;Kunkel,SL
通讯作者：
Kunkel,SL
兔中性粒细胞钙代谢的刺激依赖性变化。
影响因子：
4
作者：
Molski,TF;Naccache,PH;Sha'afi,RI
通讯作者：
Sha'afi,RI