Familial Influences on Mismatch Negativity and Its Association with Plasma Glutamate Level: A Magnetoencephalographic Study in Twins.
Familial Influences on Mismatch Negativity and Its Association with Plasma Glutamate Level: A Magnetoencephalographic Study in Twins.
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家庭对失配负性的影响及其与血浆谷氨酸水平的关联：双胞胎的脑磁图研究。
DOI：
10.1159/000449426
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Kiyoto Kasai
中科院分区：
文献类型：
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作者：
Yukika Nishimura;Yuki Kawakubo;Motomu Suga;Kenji Hashimoto;Yuichi Takei;Kunio Takei;Hideyuki Inoue;Masato Yumoto;Ryu Takizawa;Kiyoto Kasai
错配负波（MMN）或其磁对应物（磁错配负波; MMNm）被认为是精神分裂症有前途的生物标志物。MMN的脑电图研究表明，MMN的振幅具有中到高的遗传性，N-甲基-D-天冬氨酸受体依赖的谷氨酸能神经传递参与了MMN的产生。我们假设同卵双胞胎之间的差异MMMNm变量可能与血浆中的氨基酸水平的差异参与的amatergic神经传递。33对同卵双生子和10对异卵双生子进行了MMMm记录。使用204通道脑磁图记录了MMNm对音调持续时间变化、音调频率变化和音素变化的反应。其中，26个MZ和7个DZ双胞胎对进行了血液采样测定血浆氨基酸水平。MMNm峰强度在MZ和DZ双胞胎中显示出相对较高的相关性。MMNm的差异往往与MZ对内血浆氨基酸水平的差异相关，而Bonferroni校正后未观察到显著相关性。我们观察到MMMNm强度的家族特征。MMN潜伏期在MZ双胞胎的差异可能会影响谷氨酸水平和谷氨酸-谷氨酰胺循环的变化，但是，结果需要复制。
Mismatch negativity (MMN) or its magnetic counterpart (magnetic mismatch negativity; MMNm) is regarded as a promising biomarker for schizophrenia. Previous electroencephalographic studies of MMN have demonstrated a moderate-to-high heritability for MMN amplitudes.N-methyl-D-aspartate receptor-dependent glutamatergic neurotransmission is implicated in MMN generation. We hypothesized that the differences between identical twins in MMNm variables might be associated with differences in plasma levels of amino acids involved in glutamatergic neurotransmission. Thirty-three pairs of monozygotic (MZ) and 10 pairs of dizygotic (DZ) twins underwent MMNm recording. The MMNm in response to tone duration changes, tone frequency changes, and phonemic changes was recorded using 204-channel magnetoencephalography. Of these, 26 MZ and 7 DZ twin pairs underwent blood sampling for determination of plasma amino acid levels. MMNm peak strength showed relatively high correlations in both MZ and DZ twin pairs. The differences in MMNm latencies tended to correlate with the differences in plasma amino acid levels within MZ pairs, while no significant correlation was observed after the Bonferroni correction. We observed a familial trait in MMNm strength. The differences in MMN latency in MZ twins might be influenced by changes in glutamate levels and glutamate-glutamine cycling; however, the results need to be replicated.