Spatial Organization of Multisensory Responses in Temporal Association Cortex
Spatial Organization of Multisensory Responses in Temporal Association Cortex
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DOI：
10.1523/jneurosci.3437-09.2009
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发表时间：
2009-09-23
影响因子：
5.3
通讯作者：
Kayser, Christoph
中科院分区：
文献类型：
--
作者：
Dahl, Christoph D.;Logothetis, Nikos K.;Kayser, Christoph
感觉皮质中的神经元通常根据它们的反应偏好在地形上组织。我们在此表明，这种反应偏好的组织也存在于多感觉关联皮层中。利用电生理映射技术，研究了非人类灵长类动物颞上联合皮层神经元对听觉和视觉刺激的模态偏好。我们发现，倾向于同一模态（听觉或视觉）的神经元经常在近距离空间内共同出现，或者与双峰神经元混合出现。相反，偏好不同模式的神经元在空间上是分开的。当在毫米尺度上分析时，单个神经元的这种组织导致相同模态偏好的扩展斑块，揭示了优先响应相同模态的更大尺度区域。此外，我们发现神经元表现出多感觉相互作用的迹象，如超加性或亚加性反应求和，也发生在空间集群中。综上所述，这些结果揭示了在较高的联想皮层中，形态偏好的空间组织，并支持了地形组织可能作为在感觉形态内部和之间整合信息的一般原则的观点。
Neurons in sensory cortices are often topographically organized according to their response preferences. We here show that such an organization of response preferences also exists in multisensory association cortex. Using electrophysiological mappings, we probed the modality preference to auditory and visual stimuli of neurons in the superior temporal association cortex of nonhuman primates. We found that neurons preferring the same modality (auditory or visual) often co-occur in close spatial proximity or occur intermingled with bimodal neurons. Neurons preferring different modalities, in contrast, occur spatially separated. This organization at the scale of individual neurons leads to extended patches of same modality preference when analyzed at the scale of millimeters, revealing larger-scale regions that preferentially respond to the same modality. In addition, we find that neurons exhibiting signs of multisensory interactions, such as superadditive or subadditive response summation, also occur in spatial clusters. Together, these results reveal a spatial organization of modality preferences in a higher association cortex and lend support to the notion that topographical organizations might serve as a general principle of integrating information within and across the sensory modalities.