Apicobasal polarity in the kidney.
Apicobasal polarity in the kidney.
复制标题
肾脏的顶端基底极性。
DOI：
10.1016/j.yexcr.2012.02.028
复制
发表时间：
2012
影响因子：
3.7
通讯作者：
Margolis,Ben
中科院分区：
文献类型：
--
作者：
Schluter,MarcA;Margolis,Ben
上皮的尖基底极化对肾功能的许多方面至关重要。在过去的十年里，我们对这种极性背后的机制的理解取得了重大进展。对这种理解至关重要的是在上皮细胞的顶端和底外侧鉴定出一种蛋白质复合物，它们以相互拮抗的方式定义这些结构域。伴随顶端结构域和底外侧结构域形成的是高度特化的细胞连接，包括粘附连接和紧密连接。最近的研究指出极性和连接复合物在不同物种之间和不同类型的肾细胞之间的可变性。尖基底极性缺陷在包括急性肾功能衰竭和多囊肾病在内的一些疾病中是突出的。
The apicobasal polarization of epithelia is critical for many aspects of kidney function. Over the last decade there have been major advances in our understanding of the mechanisms that underlie this polarity. Critical to this understanding has been the identification of protein complexes on the apical and basolateral sides of epithelial cells that act in a mutually antagonistic manner to define these domains. Concomitant with the creation of apical and basolateral domains is the formation of highly specialized cell–cell junctions including adherens junctions and tight junctions. Recent research points to variability in the polarity and junctional complexes amongst different species and between different cell types of the kidney. Defects in apicobasal polarity are prominent in several disorders including acute renal failure and polycystic kidney disease.