INDUCTION OF HUMAN MULTINUCLEATED MONOCYTES IN CULTURE
INDUCTION OF HUMAN MULTINUCLEATED MONOCYTES IN CULTURE
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DOI：
10.1111/1523-1747.ep12481419
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发表时间：
1976-01-01
影响因子：
6.5
通讯作者：
EPSTEIN, WL
中科院分区：
文献类型：
--
作者：
BLACK, MM;FUKUYAMA, K;EPSTEIN, WL
利用人单核细胞培养研究了体外多核巨细胞的形成。多核单核细胞出现在培养过程的早期，表明它们不仅仅是在衰老培养中发现的现象。在33名正常成年人中，有4名在培养中出现了超过20%的多核形式。多核细胞发生率高的受试者早期单核细胞培养的上清液在其他培养中诱导多核细胞的形成。当多核细胞计数低的受试者的上清与其他单核细胞培养物一起孵育时，这种效果不会发生。
The formation of multinucleated giant cells in vitro has been studied using human monocyte cultures. Multinucleated monocytes appeared early in the course of the culture, indicating that they are not purely a phenomenon found only in aging cultures. In 4 of the 33 normal adults, more than 20% of multinucleated forms appeared in the cultures. Supernatants from early monocyte cultures of those subjects having a high incidence of multinucleated cells induced the formation of multinucleated cells in other cultures. This effect did not occur when supernatant from subjects with low counts of multinucleated cells were incubated with other monocyte cultures.