The roles of prostanoids in infection and sickness behaviors
The roles of prostanoids in infection and sickness behaviors
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DOI：
10.1007/s10156-008-0622-3
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发表时间：
2008-08-01
影响因子：
2.2
通讯作者：
Narumiya, Shuh
中科院分区：
文献类型：
--
作者：
Matsuoka, Toshiyuki;Narumiya, Shuh
患者的全身感染导致所谓的疾病行为，如发热、促肾上腺皮质激素释放、运动减少、社会接触丧失、厌食和睡眠增加。由于阿司匹林类非甾体抗炎药可缓解大多数这些症状，因此强烈建议前列腺素类参与疾病行为的产生。前列腺素类是由前列腺素（PGs）和血栓素（TXs）组成的一类脂质介质，在各种刺激下形成。它们包括PGD（2）、PGE（2）、PGF（2）α、PGI（2）和TXA（2）。合成后立即释放到细胞外，通过与靶细胞表面的G蛋白偶联视紫红质型受体结合发挥作用。前列腺素受体有八种类型：PGD受体、PGE受体的四种亚型、PGF受体、PGI受体和TXA受体。最近，产生了这些前列腺素类受体中的每一种都缺乏的小鼠，并且在各种实验疾病模型中对这些小鼠的检查揭示了前列腺素受体信号传导在各种病理过程中的重要作用。在这篇综述中，我们描述了几个最近的研究结果，已经解决了潜在的疾病行为的机制，并已确定的关键作用，每个前列腺素受体的信号在引发与这些疾病行为相关的应激反应。
A systemic infection in patients causes so-called sickness behaviors, such as fever generation, adrenocorticotropic hormone release, reduced locomotion, loss of social contact, anorexia, and increased sleep. As aspirin-like non-steroidal anti-inflammatory drugs alleviate most of these symptoms, the involvement of prostanoids in the generation of sickness behaviors has been strongly suggested. Prostanoids, consisting of prostaglandins (PGs) and thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. They include PGD(2), PGE(2), PGF(2)alpha, PGI(2), and TXA(2). Immediately after synthesis, they are released outside the cells, and exert their actions by binding to a G-protein-coupled rhodopsin-type receptor on the surface of target cells. There are eight types of prostanoid receptors: the PGD receptor, four subtypes of PGE receptor, the PGF receptor, the PGI receptor, and the TXA receptor. Recently, mice deficient in each of these prostanoid receptors were generated and the examination of these mice in various experimental disease models revealed the important roles of prostaglandin receptor signaling in various pathological processes. In this review, we describe several recent findings that have addressed the mechanisms underlying sickness behaviors and that have identified the critical roles of the signaling of each prostanoid receptor in the elicitation of the stress responses associated with these sickness behaviors.