Modern biooxidation : enzymes, reactions and applications
Modern biooxidation : enzymes, reactions and applications
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发表时间：
2007
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通讯作者：
R. Schmid;V. Urlacher
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作者：
R. Schmid;V. Urlacher
1 PQQ-和fad依赖性脱氢酶的生物氧化（Osao Adachi, Yoshitaka Ano, Hirohide Toyama, Kazunobu Matsushita）。1.1简介1.2膜结合酶的基本技术信息1.3 pqq依赖性脱氢酶1.4 fad依赖性脱氢酶1.5其他参考文献2漆酶的催化应用（Feng Xu, Ture Damhus, Steffen Danielsen, and Lars Henrik Ostergaard）。2.1经典漆酶的性质。2.2漆酶在工业氧化过程中的应用。2.3漆酶的最新进展。2.4漆酶催化的进一步发展。3 Baeyer-Villiger单加氧酶的生物催化范围（Marco W. Fraaije和Dick B. Janssen）。3.1简介。3.2 I型Baeyer-Villiger单加氧酶：多功能氧化生物催化剂。3.3结语。4细菌细胞色素P450单加氧酶：P450cam和p450mm -3 （Vlada B. Urlacher, Stephen G. Bell, and Luet-Lok Wong）。4.1简介。4.2细菌P450酶的生物转化。4.3 P450cam和P450BM-3的一般特征。4.4 P450工程的范围。5细胞色素P450氧化还原伙伴系统：生物多样性和生物技术的影响（Andrew W. Munro, Hazel M. Girvan, Joseph P. McVey，和Kirsty J. McLean）。5.1简介。5.2 P450氧化还原伙伴。5.3增加P450-氧化还原伙伴复杂性：黄氧doxins和多种铁氧化还毒素。5.4天然和人工。社会P450-氧化还原伴侣融合酶及其生物催化潜力。5.5驱动P450催化功能的其他途径。5.6解偶联，酶稳定性和辅酶问题。5.7未来展望。6类固醇羟基化：使用细胞色素P450酶的微生物类固醇生物转化（Matthias Bureik和Rita Bernhardt）。6.1简介。6.2细胞色素p450依赖的类固醇羟化酶系统。6.3类固醇生物转化中的天然微生物。6.4遗传莫迪。7利用微生物细胞色素P450单加氧酶进行生物转化的模块化方法（Akira Arisawa和Hitosi Agematu）。7.1简介。7.2实验大纲。7.3大肠杆菌CYP表达系统。7.4细菌CYP文库的构建。7.5细菌CYP反应阵列的构建。7.6 CYP反应阵列在生物转化筛选中的应用。8工业上的选择性微生物氧化：利用天然或重组微生物氧化烷烃、脂肪酸、杂环化合物、芳香族化合物和甘油（Albrecht Weiss）。8.1简介。8.2烃类和脂肪酸的选择性氧化。8.3芳香族化合物/精细化学品。8.4杂环化合物。8.5甘油转化为二羟基丙酮。8.6展望。9利用真菌和细菌菌株（Oreste Ghisalba和Matthias Kittelmann）制备药物代谢物。9.1简介。9.2 I期药物代谢酶。9.3药物代谢物生成的需求与“平台”。9.4微生物氧化药物代谢模型。9.5微生物与哺乳动物氧化药物代谢的相关性。9.6微生物反应与人类CYP同工酶特异性的相关性。c反应。9.7诺华的微生物羟基化研究实例。9.8天然产物的微生物氧化。9.9结论。10表达人类p450的重组酵母和细菌：用于药物发现、开发和生物技术的生物反应器（Steven P. Hanlon, Thomas Friedberg, c . Roland Wolf， Oreste Ghisalba和Matthias Kittelmann）。10.1背景。10.2不同模型中P450水平和酶活性的比较。10.3大肠杆菌P450表达系统在生物反应器中的应用。10.4结论。11人细胞色素P450单加氧酶-底物特异性和区域选择性的一般模型（Jurgen Pleiss）。11.1引言。11.2我们能从序列中学到什么？11.3我们从结构中学到了什么？11.4结论：12种回收和取代NAD(P)H作为CYP辅因子的方法（Dirk Holtmann和Jens Schrader）。12.1简介。12.2辅助因子的化学替代。12.3辅助因子的酶促再生。12.4 P450系统中辅助因子替代或再生的光化学方法。12.5辅助因子替代或再生的电化学系统。12.6氧化还原介质。12.7分子生物学方法。12.8结论与展望。索引。
1 Biooxidation with PQQ- and FAD-Dependent Dehydrogenases (Osao Adachi, Yoshitaka Ano, Hirohide Toyama, and Kazunobu Matsushita). 1.1 Introduction. 1.2 Basic Technical Information Regarding Membrane-bound Enzymes. 1.3 PQQ-Dependent Dehydrogenases. 1.4 FAD-Dependent Dehydrogenase. 1.5 Miscellaneous. References. 2 Catalytic Applications of Laccase (Feng Xu, Ture Damhus, Steffen Danielsen, and Lars Henrik Ostergaard). 2.1 Properties of Classical Laccase. 2.2 Applications of Laccase for Industrial Oxidation Processes. 2.3 More Recent Developments. 2.4 Further Developing Laccase Catalysis. 3 Biocatalytic Scope of Baeyer-Villiger Monooxygenases (Marco W. Fraaije and Dick B. Janssen). 3.1 Introduction. 3.2 Type I Baeyer-Villiger Monooxygenases: Versatile Oxidative Biocatalysts. 3.3 Concluding Remarks. 4 The Bacterial Cytochrome P450 Monooxygenases: P450cam and P450BM-3 (Vlada B. Urlacher, Stephen G. Bell, and Luet-Lok Wong). 4.1 Introduction. 4.2 Biotransformation by Bacterial P450 Enzymes. 4.3 General Features of P450cam and P450BM-3. 4.4 The Scope of P450 Engineering. 5 Cytochrome P450 Redox Partner Systems: Biodiversity and Biotechnological Implications (Andrew W. Munro, Hazel M. Girvan, Joseph P. McVey, and Kirsty J. McLean). 5.1 Introduction. 5.2 P450 Redox Partners. 5.3 Increasing P450-Redox Partner Complexity: Flavodoxins and Diverse Ferredoxins. 5.4 Natural and Arti. cial P450-Redox Partner Fusion Enzymes and their Biocatalytic Potential. 5.5 Other Routes to Driving P450 Catalytic Function. 5.6 Uncoupling, Enzyme Stability and Coenzyme Issues. 5.7 Future Prospects. 6 Steroid Hydroxylation: Microbial Steroid Biotransformations Using Cytochrome P450 Enzymes (Matthias Bureik and Rita Bernhardt). 6.1 Introduction. 6.2 Cytochrome P450-Dependent Steroid Hydroxylase Systems. 6.3 Native Microorganisms in Steroid Biotransformation. 6.4 Genetically Modi. ed Microorganisms in Steroid Biotransformation. 6.5 Synopsis and Concluding Remarks. 7 A Modular Approach to Biotransformation Using Microbial Cytochrome P450 Monooxygenases (Akira Arisawa and Hitosi Agematu). 7.1 Introduction. 7.2 Experimental Outline. 7.3 Bacterial CYP Expression System in E. coli. 7.4 Construction of a Bacterial CYP Library. 7.5 Construction of a Bacterial CYP Reaction Array. 7.6 Application of the CYP Reaction Array to Biotransformation Screening. 8 Selective Microbial Oxidations in Industry: Oxidations of Alkanes, Fatty Acids, Heterocyclic Compounds, Aromatic Compounds and Glycerol Using Native or Recombinant Microorganisms (Albrecht Weiss). 8.1 Introduction. 8.2 Selective Oxidation of Hydrocarbons and Fatty Acids. 8.3 Aromatic Compounds/Fine Chemicals. 8.4 Heterocyclic Compounds. 8.5 Glycerol Conversion to Dihydroxyacetone. 8.6 Perspectives. 9 Preparation of Drug Metabolites using Fungal and Bacterial Strains (Oreste Ghisalba and Matthias Kittelmann). 9.1 Introduction. 9.2 Phase I Drug-Metabolizing Enzymes. 9.3 Needs and "Platforms" for the Generation of Drug Metabolites. 9.4 Microbial Models for Oxidative Drug Metabolism. 9.5 Correlation of Microbial and Mammalian Oxidative Drug Metabolism. 9.6 Correlation of Microbial Reactions with Human CYP Isozyme-Speci. c Reactions. 9.7 Novartis Research Examples of Microbial Hydroxylations. 9.8 Microbial Oxidation of Natural Products. 9.9 Conclusions. 10 Recombinant Yeast and Bacteria that Express Human P450s: Bioreactors for Drug Discovery, Development, and Biotechnology (Steven P. Hanlon, Thomas Friedberg, C. Roland Wolf, Oreste Ghisalba, and Matthias Kittelmann). 10.1 Background. 10.2 Comparison of P450 Levels and Enzymic Activities in Various Models. 10.3 Use of E. coli P450 Expression Systems in Bioreactors. 10.4 Conclusion. 11 Human Cytochrome P450 Monooxygenases - a General Model of Substrate Specifi city and Regioselectivity (Jurgen Pleiss). 11.1 Introduction. 11.2 What Can We Learn From Sequence? 11.3 What Can We Learn from Structure? 11.4 Conclusion. 12 Approaches to Recycling and Substituting NAD(P)H as a CYP Cofactor (Dirk Holtmann and Jens Schrader). 12.1 Introduction. 12.2 Chemical Substitution of Cofactors. 12.3 Enzymatic Regeneration of Cofactors. 12.4 Photochemical Approaches to Substituting or Regenerating Cofactors for P450 Systems. 12.5 Electrochemical Systems for Substitution or Regeneration of Cofactors. 12.6 Redox Mediators. 12.7 Molecular Biological Approaches. 12.8 Conclusion and Outlook. Index.