Beyond Skin Testing: State of the Art and New Horizons in Food Allergy Diagnostic Testing
Beyond Skin Testing: State of the Art and New Horizons in Food Allergy Diagnostic Testing
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DOI：
10.1016/j.iac.2011.11.002
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发表时间：
2012-02-01
影响因子：
2.6
通讯作者：
Sampson, Hugh A.
中科院分区：
文献类型：
--
作者：
Caubet, Jean-Christoph;Sampson, Hugh A.
食物过敏影响约1%至10.8%的一般人群，其患病率似乎正在增加。准确的诊断尤其重要，因为误诊可能导致危及生命的反应或不必要的限制性饮食。然而，目前在临床实践中使用的过敏试验具有有限的准确性，并且通常需要被认为是金标准的口服食物挑战来确认或排除食物过敏。本文综述了近年来食物过敏诊断的新方法，包括分子诊断技术和功能检测技术，并沿着其潜在的临床应用。
Food allergy affects approximately 1% to 10.8% of the general population, and its prevalence seems to be increasing. An accurate diagnosis is particularly important because a misdiagnosis could lead to life-threatening reactions or to unnecessary restrictive diets. However, allergy tests currently used in clinical practice have limited accuracy, and an oral food challenge, considered as the gold standard, is often required to confirm or exclude a food allergy. This article reviews several promising novel approaches for the diagnosis of food allergy, such as new molecular diagnostic technologies and functional assays, along with their potential clinical applications.