Increased neural response to social rejection in major depression
Increased neural response to social rejection in major depression
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DOI：
10.1002/da.22665
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发表时间：
2017-11-01
影响因子：
7.4
通讯作者：
Steele, J. Douglas
中科院分区：
文献类型：
--
作者：
Kumar, Poornima;Waiter, Gordon D.;Steele, J. Douglas
成为社区的一部分对生存至关重要，重度抑郁症（MDD）患者对人际压力更敏感，这使他们更容易在未来发作。社会排斥是抑郁症的一个关键风险因素，据说它会增加人际压力，从而损害社会功能。因此，理解重度抑郁症中社会排斥的神经关联是至关重要的。为此，我们在一个改良的网球传球游戏中扫描了15名服药的MDD和17名健康的个体，参与者暴露于越来越高的社会排斥水平。研究了不同群体对社会排斥的神经反应。结果我们发现，与对照组相比，重度抑郁症个体表现出更大的杏仁核、脑岛和腹外侧前额叶皮层激活，以增加社会排斥，这与所有参与者的享乐音调和自尊得分呈负相关。结论这些初步结果支持了抑郁症与过度活跃的社会排斥反应有关的假设。这些发现强调了研究抑郁症患者的社会互动的重要性，因为它们经常导致社交退缩和孤立。
BackgroundBeing a part of community is critical for survival and individuals with major depressive disorder (MDD) have a greater sensitivity to interpersonal stress that makes them vulnerable to future episodes. Social rejection is a critical risk factor for depression and it is said to increase interpersonal stress and thereby impairing social functioning. It is therefore critical to understand the neural correlates of social rejection in MDD.MethodsTo this end, we scanned 15 medicated MDD and 17 healthy individuals during a modified cyberball passing game, where participants were exposed to increasing levels of social exclusion. Neural responses to increasing social exclusion were investigated and compared between groups.ResultsWe showed that compared to controls, MDD individuals exhibited greater amygdala, insula, and ventrolateral prefrontal cortex activation to increasing social exclusion and this correlated negatively with hedonic tone and self-esteem scores across all participants.ConclusionsThese preliminary results support the hypothesis that depression is associated with hyperactive response to social rejection. These findings highlight the importance of studying social interactions in depression, as they often lead to social withdrawal and isolation.