DNA ploidy and its clinical implications in gastric cancer
DNA ploidy and its clinical implications in gastric cancer
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DOI：
10.1067/msy.2002.119306
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发表时间：
2002-01-01
期刊：
影响因子：
3.8
通讯作者：
Maehara, Y
中科院分区：
文献类型：
--
作者：
Baba, H;Korenaga, D;Maehara, Y
背景胃癌的生物学特征主要取决于个体癌细胞的遗传改变。为了精确预测个体癌症的生物学行为和临床结果，澄清每个病例中癌细胞的DNA谱可能是重要的。本文综述了近20年来在英文文献中发表的有关乳腺癌DNA倍体的重要研究结果。非整倍体胃癌具有较高的增殖活性和较高的转移或侵袭潜能，因此与二倍体肿瘤相比预后较差。胃癌DNA倍体分析可为临床诊断、治疗和预后提供有用的信息。染色体不稳定性与DNA倍性的关系有待进一步研究。
Background. Biological characteristics of gastric cancer depend mostly or genetic alterations in the cancer cells of individuals. To precisely predict the biological behavior and clinical outcome of individual cancer, it may be important to clarify the DNA profiles of cancer cells in each case.Methods. We have reviewed the most important results of studies on DNA ploidy of gamic cancer published in the English literature during the last 2 decades.Results. Gastric carcinoma with aneuploidy has been shown to have a high proliferative activity and a high metastatic or invasive potential, thus leading to a poor prognosis as compared to diploid tumors.Conclusion. Analyses of DNA ploidy in gastric cancer may provide clinically useful information on diagnostic, therapeutic, and prognostic aspects. Further investigations way be needed to clarify the relationship between chromosome instability and DNA ploidy.