MULTIPLE PATHWAYS FROM THE SUPERIOR COLLICULUS TO THE EXTRAGENICULATE VISUAL THALAMUS OF THE CAT
MULTIPLE PATHWAYS FROM THE SUPERIOR COLLICULUS TO THE EXTRAGENICULATE VISUAL THALAMUS OF THE CAT
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DOI：
10.1002/cne.902710308
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发表时间：
1988-05-15
影响因子：
2.5
通讯作者：
CHALUPA, LM
中科院分区：
文献类型：
--
作者：
ABRAMSON, BP;CHALUPA, LM
通过麦芽凝集素 - 辣根过氧化物酶（WGA - HRP）的顺行和逆行运输，研究了猫上丘到膝状体外视觉丘脑的投射。采用乙酰硫代胆碱酯酶（ATChE）染色来促进丘脑后部区域的区分。根据终末标记的分布以及投射神经元的层状起源，描绘了四条通路。浅灰质层（主要是Ⅱ和Ⅲ亚层）的细胞支配后外侧核（LP）内的两个区域：乙酰硫代胆碱酯酶染色较深的内侧区，以及靠近丘脑枕的外侧区的一个局限部分。发现这两条通路都具有局部定位组织。通过使用荧光逆行示踪剂——快蓝和罗丹明标记的微球，确定LP内侧区和外侧区的输入主要来自不同的细胞群，因为很少发现神经元被双重标记。第三条通路主要起源于视层的细胞，终止于LP富含胆碱酯酶区域下方的一个区域，该区域被指定为LP的腹侧部。第四条投射主要从中间灰质层到膝状体上复合体。这四条通路中的每一条都来自具有不同形态特征的神经元群，并且在大多数情况下，每条通路都由形态相似的细胞组成。这些结果表明，来自上丘的视觉信息通过可能具有不同功能的多条通路传递到膝状体外丘脑。
The projections from the cat''s superior colliculus to the extrageniculate visual thalamus were examined by the anterograde and retrograde transport of WGA-HRP. An acetylthiocholinesterase (ATChE) stain was employed to facilitate the differentiation of regions within the posterior thalamus. On the basis of the distribution of terminal label as well as the laminar origin of projection neurons, four pathways were delineated. Cells in the stratum griseum superficiale (primarily sublaminae II and III) innervate two regions within the nucleus lateralis posterior (LP): the medial zone, which stains darkly or ATChE, and a restricted portion of the lateral zone, adjacent to the pulvinar. Both of these pathways were found to be topographically organized. By using the fluorescent retrograde tracers, fast blue and rhodamine labeled microspheres, it was determined that the inputs to the medial and lateral zones of LP originate primarily from separate cell populations since very few neurons were found to be double-labeled. A third pathway originates principally from cells in the stratum opticum and terminates in an area just below the cholinesterase-rich region of the LP, designated as the ventral division of the LP. The fourth projection is primairly from the stratum griseum intermedium to the suprageniculate complex. Each of these four pathways arises from a population of neurons with heterogeneous morphological characteristics, and for the most part, each pathway comprises morphologically similar cells. These results suggest that visual information from the superior colliculus is conveyed to the extrageniculate thalamus via multiple pathways that may subserve diverse functions.