Mechanisms of receptor tyrosine kinase activation in cancer.
Mechanisms of receptor tyrosine kinase activation in cancer.
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DOI：
10.1186/s12943-018-0782-4
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发表时间：
2018-02-19
期刊：
影响因子：
37.3
通讯作者：
Lovly CM
中科院分区：
文献类型：
--
作者：
Du Z;Lovly CM
受体酪氨酸激酶(RTK)在多种细胞过程中发挥重要作用，包括生长、运动、分化和代谢。因此，RTK信号的失调会导致多种人类疾病，最明显的是癌症。最近的大规模基因组研究揭示了RTK编码基因的各种变化，如EGFR、HER2/ErbB2和MET等。人类癌症中RTK的异常激活有四种主要机制：功能获得突变、基因组扩增、染色体重排和/或自分泌激活。在这篇手稿中，我们回顾了RTK在正常生理条件下被激活的过程，并讨论了RTK在人类癌症中异常激活的几个机制。了解这些机制对抗癌治疗的选择具有重要意义。
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK signaling leads to an assortment of human diseases, most notably, cancers. Recent large-scale genomic studies have revealed the presence of various alterations in the genes encoding RTKs such as EGFR, HER2/ErbB2, and MET, amongst many others. Abnormal RTK activation in human cancers is mediated by four principal mechanisms: gain-of-function mutations, genomic amplification, chromosomal rearrangements, and / or autocrine activation. In this manuscript, we review the processes whereby RTKs are activated under normal physiological conditions and discuss several mechanisms whereby RTKs can be aberrantly activated in human cancers. Understanding of these mechanisms has important implications for selection of anti-cancer therapies.
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影响因子：
4.1
作者：
Cho, William C. S.;Chow, Andrew S. C.;Au, Joseph S. K.
通讯作者：
Au, Joseph S. K.
DOI：
10.1056/nejmoa1007056
发表时间：
2010-10-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Butrynski JE;D'Adamo DR;Hornick JL;Dal Cin P;Antonescu CR;Jhanwar SC;Ladanyi M;Capelletti M;Rodig SJ;Ramaiya N;Kwak EL;Clark JW;Wilner KD;Christensen JG;Jänne PA;Maki RG;Demetri GD;Shapiro GI
通讯作者：
Shapiro GI
影响因子：
5.8
作者：
Chmielecki, Juliann;Ross, Jeffrey S.;Stephens, Philip J.
通讯作者：
Stephens, Philip J.
影响因子：
5.6
作者：
Coffin, Cheryl M.;Hornick, Jason L.;Fletcher, Christopher D. M.
通讯作者：
Fletcher, Christopher D. M.
影响因子：
3.4
作者：
Cappuzzo, Federico;Sacconi, Andrea;Blandino, Giovanni
通讯作者：
Blandino, Giovanni