Plasma fibrinogen levels, other cardiovascular risk factors, and age-related maculopathy -: The Blue Mountains Eye Study
Plasma fibrinogen levels, other cardiovascular risk factors, and age-related maculopathy -: The Blue Mountains Eye Study
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DOI：
10.1001/archopht.116.5.583
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发表时间：
1998-05-01
影响因子：
--
通讯作者：
Wang, JJ
中科院分区：
文献类型：
--
作者：
Smith, W;Mitchell, P;Wang, JJ
目的：评估年龄相关性黄斑变性 (ARM) 阶段与心血管疾病和心血管疾病危险因素之间的关系，包括血脂和血浆纤维蛋白原水平、吸烟、心血管事件、全身性高血压、糖尿病和肥胖。 设计：对来自特定地理区域的 3654 名受试者进行横断面研究，通过视网膜照片的屏蔽分级确定患有晚期年龄相关性黄斑变性 (ARMD) 和早期 ARM 的受试者。病史、体检结果和空腹血样提供了可能的危险因素的数据。使用 Logistic 回归、调整年龄、性别和可能的混杂因素以及双因素方差分析来评估相关性。结果：与 ARM 显着相关的唯一因素包括 2 个已确定的危险因素：吸烟和 ARMD 家族史（晚期 ARMD 的比值比分别为 4.1 和 4.2），以及 2 个变量：体重指数（与早期 ARMD 的正常体重指数相比，肥胖的比值比为 1.78）和血浆纤维蛋白原水平（与纤维蛋白原水平 >4.5 g/L [最高四分位数]相比，优势比为 6.7）
Objective: To assess the relationship between stages of age-related maculopathy (ARM) and cardiovascular disease and cardiovascular disease risk factors, including serum lipid and plasma fibrinogen levels, smoking, cardiovascular events, systemic hypertension, diabetes mellitus, and obesity.Design: A cross-sectional study of 3654 subjects from a defined geographic area identified subjects with late age-related macular degeneration (ARMD) and early ARM from the masked grading of retinal photographs. The history, physical examination findings, and fasting blood samples provided data on possible risk factors. Logistic regression, adjusting for age, sex, and possible confounders, and 2-way analysis of variance were used to assess associations.Results: The only factors significantly associated with ARM included the 2 established risk factors, smoking and family history of ARMD (odds ratios, 4.1 and 4.2, for late ARMD, respectively), and the 2 variables, body mass index (odds ratio, 1.78 for obese compared with normal body mass index for early ARM) and plasma fibrinogen level (odds ratio, 6.7 for a fibrinogen level of >4.5 g/L [highest quartile] compared with a fibrinogen level of