Masked Hypertension and Prehypertension: Diagnostic Overlap and Interrelationships With Left Ventricular Mass: The Masked Hypertension Study
Masked Hypertension and Prehypertension: Diagnostic Overlap and Interrelationships With Left Ventricular Mass: The Masked Hypertension Study
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DOI：
10.1038/ajh.2012.15
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发表时间：
2012-06-01
影响因子：
3.2
通讯作者：
Schwartz, Joseph E.
中科院分区：
文献类型：
--
作者：
Shimbo, Daichi;Newman, Jonathan D.;Schwartz, Joseph E.
背景：相对于持续的正常血压，非典型高血压（MHT）和高血压前期（PHT）都与心血管疾病（CVD）风险增加有关。本研究探讨了MHT和PHT之间的诊断重叠，以及它们与左心室（LV）质量指数（LVMI）的相互关系，LVMI是心血管终末器官损伤的标志物。方法研究护士在3周内进行了3次手动门诊血压（CBP）测量（共9个读数，取平均值），813名未接受过高血压治疗的参与者，来自掩蔽高血压研究，一项正在进行的基于工作场所的人群研究。使用SpaceLabs 90207监测仪评估24小时动态血压（ABP）。在813名参与者中，769名（94.6%）CBP水平正常（= 135/85 mm Hg），287名（37.3%）有PHT（平均CBP 120-139/80-89 mm Hg）。83.8%的MHT参与者患有PHT，34.1%的PHT参与者患有MHT。当CBP为最佳时，MHT不常见（3.9%），
BACKGROUNDMasked hypertension (MHT) and prehypertension (PHT) are both associated with an increase in cardiovascular disease (CVD) risk, relative to sustained normotension. This study examined the diagnostic overlap between MHT and PHT, and their interrelationships with left ventricular (LV) mass index (LVMI), a marker of cardiovascular end-organ damage.METHODSA research nurse performed three manual clinic blood pressure (CBP) measurements on three occasions over a 3-week period (total of nine readings, which were averaged) in 813 participants without treated hypertension from the Masked Hypertension Study, an ongoing worksite-based, population study. Twenty-four-hour ambulatory blood pressure (ABP) was assessed by using a SpaceLabs 90207 monitor. LVMI was determined by echocardiography in 784 (96.4%) participants.RESULTSOf the 813 participants, 769 (94.6%) had normal CBP levels (= 135/85 mm Hg) and 287 (37.3%) had PHT (mean CBP 120-139/80-89 mm Hg). 83.8% of MHT participants had PHT and 34.1% of PHT participants had MHT. MHT was infrequent (3.9%) when CBP was optimal (