Amino Acid-Mediated Metabolism: A New Power to Influence Properties of Stem Cells
Amino Acid-Mediated Metabolism: A New Power to Influence Properties of Stem Cells
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氨基酸介导的代谢：影响干细胞特性的新力量
DOI：
10.1155/2019/6919463
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发表时间：
2019-12
影响因子：
4.3
通讯作者：
Jin Feng
中科院分区：
文献类型：
--
作者：
Liu Jilan;Qin Xianyun;Pan Dongfeng;Zhang Bin;Jin Feng
干细胞的自我更新和分化潜能依赖于氨基酸（AA）代谢。我们回顾了有关癌症和非癌症干细胞代谢偏好的文献。AA代谢的平衡负责维持非癌干细胞的功能，并且改变AA水平可以影响癌症干细胞的恶性生物学行为。AA被认为是参与代谢的营养物质，在维持正常干细胞的活性和肿瘤干细胞的治疗效果方面起着关键作用。靶向AA代谢有助于抑制癌症干细胞的干性，并重塑正常干细胞的功能。本文综述了近5年来国内外从营养学和基因组学角度对AA在不同干细胞中的代谢特点和调控途径的研究进展。此外，我们简要介绍了新的治疗方式，可能有助于消除癌症干细胞利用营养剥夺。了解AA摄取特性有助于研究人员确定不同干细胞对AA的偏好，并使临床医生能够及时干预，以专门针对细胞行为。
The self-renewal and differentiation potentials of stem cells are dependent on amino acid (AA) metabolism. We review the literature on the metabolic preference of both cancer and noncancer stem cells. The balance in AA metabolism is responsible for maintaining the functionality of noncancer stem cells, and altering the levels of AAs can influence the malignant biological behavior of cancer stem cells. AAs are considered nutrients participating in metabolism and playing a critical role in maintaining the activity of normal stem cells and the effect of therapy of cancer stem cells. Targeting AA metabolism helps inhibit the stemness of cancer stem cells and remodels the function of normal stem cells. This review summarizes the metabolic characteristics and regulation pathways of AA in different stem cells, not only from the nutritional perspective but also from the genomic perspective that have been reported in the recent five years. In addition, we briefly survey new therapeutic modalities that may help eradicate cancer stem cells by exploiting nutrient deprivation. Understanding AA uptake characteristics helps researchers define the preference for AA in different stem cells and enables clinicians make timely interventions to specifically target the cell behavior.
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影响因子：
5.9
作者：
Comes, Stefania;Gagliardi, Miriam;Laprano, Nicola;Fico, Annalisa;Cimmino, Amelia;Palamidessi, Andrea;De Cesare, Dario;De Falco, Sandro;Angelini, Claudia;Scita, Giorgio;Patriarca, Eduardo J.;Matarazzo, Maria R.;Minchiotti, Gabriella
通讯作者：
Minchiotti, Gabriella
DOI：
10.1126/science.1226603
发表时间：
2013-01-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Shyh-Chang N;Locasale JW;Lyssiotis CA;Zheng Y;Teo RY;Ratanasirintrawoot S;Zhang J;Onder T;Unternaehrer JJ;Zhu H;Asara JM;Daley GQ;Cantley LC
通讯作者：
Cantley LC
代谢重编程协调 CD4 T 细胞免疫状态并恢复自身免疫诱导的扩张型心肌病小鼠的心脏功能障碍
影响因子：
5
作者：
Wu Jian;Sun Ping;Chen Qi;Sun Yong;Shi Ming;Mang Ge;Yu Shan;Zheng Yang;Li Zhaoying;Sun Meng;Fang Shaohong;Zhang Yongxiang;Tian Jinwei;Mingyan E;Zhang Maomao;Yu Bo
通讯作者：
Yu Bo
色氨酸衍生物调节干细胞样癌细胞中 Oct4 的转录。
影响因子：
16.6
作者：
Cheng, Jie;Li, Wenxin;Kang, Bo;Zhou, Yanwen;Song, Jiasheng;Dan, Songsong;Yang, Ying;Zhang, Xiaoqian;Li, Jingchao;Yin, Shengyong;Cao, Hongcui;Yao, Hangping;Zhu, Chenggang;Yi, Wen;Zhao, Qingwei;Xu, Xiaowei;Zheng, Min;Zheng, Shusen;Li, Lanjuan;Shen, Binghui;Wang, Ying-Jie
通讯作者：
Wang, Ying-Jie
影响因子：
29
作者：
Yang L;Achreja A;Yeung TL;Mangala LS;Jiang D;Han C;Baddour J;Marini JC;Ni J;Nakahara R;Wahlig S;Chiba L;Kim SH;Morse J;Pradeep S;Nagaraja AS;Haemmerle M;Kyunghee N;Derichsweiler M;Plackemeier T;Mercado-Uribe I;Lopez-Berestein G;Moss T;Ram PT;Liu J;Lu X;Mok SC;Sood AK;Nagrath D
通讯作者：
Nagrath D