Assembly of hair bundles, an amazing problem for cell biology.
Assembly of hair bundles, an amazing problem for cell biology.
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DOI：
10.1091/mbc.e14-04-0940
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发表时间：
2015-08-01
影响因子：
3.3
通讯作者：
Barr-Gillespie PG
中科院分区：
文献类型：
--
作者：
Barr-Gillespie PG
毛束——脊椎动物内耳毛细胞的感觉细胞器——是细胞组装复杂、优雅结构的能力的例证。为了对外力作出适当的机械传导，并传递有关声音和运动的信息，束的适当结构是必需的。束中含有数量严格控制的充满肌动蛋白的立体纤毛，这些纤毛以精确的高度排列成行。事实上，许多使毛细胞细胞骨架蛋白失效的耳聋突变也会破坏毛细胞束。束组装是分子和细胞系统生物学中一个容易处理的问题。立体纤毛结构变化的序列是已知的，可能涉及少量的蛋白质。
The hair bundle—the sensory organelle of inner-ear hair cells of vertebrates—exemplifies the ability of a cell to assemble complex, elegant structures. Proper construction of the bundle is required for proper mechanotransduction in response to external forces and to transmit information about sound and movement. Bundles contain tightly controlled numbers of actin-filled stereocilia, which are arranged in defined rows of precise heights. Indeed, many deafness mutations that disable hair-cell cytoskeletal proteins also disrupt bundles. Bundle assembly is a tractable problem in molecular and cellular systems biology; the sequence of structural changes in stereocilia is known, and a modest number of proteins may be involved.