Molecular pathways: autophagy in cancer--a matter of timing and context.
Molecular pathways: autophagy in cancer--a matter of timing and context.
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DOI：
10.1158/1078-0432.ccr-13-2438
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发表时间：
2015-02-01
期刊：
影响因子：
--
通讯作者：
Xia B
中科院分区：
文献类型：
--
作者：
Cicchini M;Karantza V;Xia B
Autophagy is an intracellular self-digestion mechanism, by which cellular components are sorted into double-membrane autophagosomes and delivered to lysosomes for degradation. Cells utilize autophagy to dispose of wastes and eliminate hazards, while recycling nutrients and tuning metabolism in the process. Through these functions, autophagy promotes cell fitness, genome integrity, tissue homeostasis, and cell survival and growth under stress. Autophagy up- and down-regulation have both been found in human cancers, suggesting a complex role in tumor development. Accumulating results from autophagy-deficient mice and mouse models of human cancers have demonstrated that autophagy generally suppresses tumor initiation, but promotes tumor progression, in a manner that is dependent on timing and context and modified by specific tumorigenic events. Given the role of autophagy in facilitating tumor growth, autophagy inhibition has gained wide attention as a potential anticancer therapy. Here, we summarize relevant genetic, preclinical and clinical studies and discuss the multi-faceted role of autophagy in cancer, as well as the prospects of autophagy inhibition for cancer therapy.
