Bipolar disorder and schizophrenia - Convergent molecular data
Bipolar disorder and schizophrenia - Convergent molecular data
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DOI：
10.1385/nmm:5:1:109
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发表时间：
2004-01-01
影响因子：
3.5
通讯作者：
Berrettini, W
中科院分区：
文献类型：
--
作者：
Berrettini, W
双相情感障碍(BPD)和精神分裂症(SZ)可能有一些共同的易感基因，尽管目前的病因学将它们分为不重叠的类别。共有遗传因素的证据包括流行病学特征、家族性研究以及已证实的BPD和/或SZ的重叠。对这些数据的回顾表明，有五个基因组区域可能代表BPD和SZ共同的遗传易感性。随着这些已确认的联系的基因被识别，当前的病因学必须改变，以反映关于BPD和SZ共同病因的新知识。
Bipolar disorder (BPD) and schizophrenia (SZ) may have some common susceptibility genes, despite that current nosology separates them into nonoverlapping categories. The evidence for shared genetic factors includes epidemiologic characteristics, family studies, and overlap in confirmed linkages of BPD and/or SZ. Review of these data indicates that there are five genomic regions that may represent shared genetic susceptibility of BPD and SZ. As the genes underlying these confirmed linkages are identified, the current nosology must be changed to reflect the new knowledge concerning the shared etiologies of BPD and SZ.