THE EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON ODOR ASSOCIATIVE LEARNING IN RATS
THE EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON ODOR ASSOCIATIVE LEARNING IN RATS
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DOI：
10.1016/0892-0362(88)90036-0
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发表时间：
1988-07-01
影响因子：
2.9
通讯作者：
RILEY, EP
中科院分区：
文献类型：
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作者：
BARRON, S;GAGNON, WA;RILEY, EP
在妊娠第 6-20 天，通过含有 35% 乙醇衍生热量 (35% EDC) 或 0% EDC 的流质饮食对怀孕女性进行酒精摄入。还包括一个即兴实验室食物组（LC）。在实验 1 中，我们对 10 天大的后代的气味厌恶学习进行了检查。虽然 0% EDC 和 LC 组都表现出对气味的厌恶，但 35% EDC 的后代却没有。在实验 2 中，以食欲范式评估了三天大的后代的学习情况。再次，35% 的 EDC 后代没有学习的证据。实验 3 检查了成人的气味厌恶学习情况。暴露于酒精的后代和对照组都同样很好地了解了气味关联。这些发现表明，气味联想学习是幼鼠酒精相关学习缺陷的敏感指标，尽管这些缺陷可能会随着后代的成熟而消失。由于气味关联在新生儿行为中起着至关重要的作用，这些缺陷可能有助于解释产前酒精暴露后注意到的其他行为异常。
Alcohol was administered to pregnant females via a liquid diet that contained either 35% ethanol-derived calories (35% EDC) or 0% EDC on gestation days 6-20. An ad lib lab chow group (LC) was also incuded. In Experiment 1, odor-aversion learning was examined in 10-day-old offspring. While both the 0% EDC and LC groups displayed odor aversions, the 35% EDC offspring did not. In Experiment 2, learning was assessed in an appetitive paradigm in three-day-old offspring. Once again, the 35% EDC offspring no evidence of learning. Experiment 3 examined odor-aversion learning in adults. Both alcohol-exposed offspring and controls learned the odor association equally well. These findings suggest that odor associative learning is a sensitive indicator for alcohol-related learning deficits in rat pups, although these deficits may dissipate as the offspring matures. Since odor associations play a critical role in neonatal behaviors, these deficits may help explain other behavioral anomalies noted following prenatal alcohol exposure.