Prevalence of heart failure and left ventricular dysfunction in the general population - The Rotterdam Study
Prevalence of heart failure and left ventricular dysfunction in the general population - The Rotterdam Study
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DOI：
10.1053/euhj.1998.1239
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发表时间：
1999-03-01
影响因子：
39.3
通讯作者：
Grobbee, DE
中科院分区：
文献类型：
--
作者：
Mosterd, A;Hoes, AW;Grobbee, DE
目的确定一般人群中心力衰竭和有症状及无症状左心室收缩功能不全的患病率。方法和结果在鹿特丹研究的5540名参与者中（年龄68.9 ± 8.7岁，2251名男性）年龄55-95岁，通过评估症状和体征确定心力衰竭的存在（呼吸短促、踝关节水肿和肺捻发音）和使用心力衰竭药物。在2267名受试者（年龄65.7 ± 7.4岁，1028名男性）中测量了短轴缩短分数。心力衰竭的总体患病率为3.9%（95%CI 3.0 +/- 4.7），男性和女性之间没有差异。患病率随着年龄的增长而增加，但男性患病率最高的年龄组除外。缩短率在女性中更高，并没有随着年龄的增长而明显下降。男性左心室收缩功能障碍（缩短分数< = 25%）的患病率（5.5%，95%CI 4.1-7.0）比女性（2.2%，95%CI 1.4-3.2）高出约2.5倍。60%的人与左心室收缩功能障碍没有任何症状或体征的心力衰竭在all.Conclusions心力衰竭的患病率是可观的，并没有男女之间的差异。大多数左心室收缩功能障碍患者可视为无症状左心室收缩功能障碍。
Aims To determine the prevalence of heart failure and symptomatic as well as asymptomatic left ventricular systolic dysfunction in the general population.Methods and Results In 5540 participants of the Rotterdam Study (age 68.9 +/- 8.7 years, 2251 men) aged 55-95 years, the presence of heart failure was determined by assessment of symptoms and signs (shortness of breath, ankle oedema and pulmonary crepitations) and use of heart failure medication. In 2267 subjects (age 65.7 +/- 7.4 years, 1028 men) fractional shortening was measured. The overall prevalence of heart failure was 3.9% (95% CI 3.0 +/- 4.7) and did not differ between men and women. The prevalence increased with age, with the exception of the highest age group in men. Fractional shortening was higher in women and did not decrease appreciably with age. The prevalence of left ventricular systolic dysfunction (fractional shortening < = 25%) was approximately 2.5 times higher in men (5.5%, 95% CI 4.1-7.0) than in women (2.2%, 95% CI 1.4-3.2). Sixty percent of persons with left ventricular systolic dysfunction had no symptoms or signs of heart failure at all.Conclusions The prevalence of heart failure is appreciable and does not differ between men and women. The majority of persons with left ventricular systolic dysfunction can be regarded as having asymptomatic left ventricular systolic dysfunction.