In vivo evaluation of a new sealant material on a rat lung air leak model
In vivo evaluation of a new sealant material on a rat lung air leak model
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DOI：
10.1002/jbm.1066
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发表时间：
2001-12-05
期刊：
影响因子：
--
通讯作者：
Shimizu, Y
中科院分区：
文献类型：
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作者：
Kobayashi, H;Sekine, T;Shimizu, Y
以白蛋白为基础的水凝胶密封剂(ABHS)防止肺部手术后缝合线漏气的能力通过与纤维蛋白胶(FG)的比较进行评估。采用标准切开的大鼠肺组织作为漏气模型，测量ABHS和FG的爆裂压力。FG组和ABHS组在0时刻的平均爆裂压分别为30.8±15.2和77.5±19.1毫米汞柱。第3天ABHS(76.3+/-15.8 mm Hg)仍显著高于FG(60.0+/-21.9 mm Hg)(P<；0.05)。在第7天，FG组(71.2+/-18.6 mm Hg)和ABHS组(88.8+/-11.7 mm Hg)之间没有统计学差异。第14天的组织学检查显示，两种封闭剂在伤口处都看不到，也没有不良组织反应的证据。结论：ABHS具有良好的密封性，是治疗肺部手术漏气的一种替代材料。(C)2001年John Wiley&Sons，Inc.
The ability of an albumin-based hydrogel sealant (ABHS) to prevent air leakage through the suture line after pulmonary surgery was evaluated by comparison with that of a fibrin glue (FG). As an air-leak model, a rat lung was used in which a standard incision was made and the burst pressure for ABHS and FG was measured. The average burst pressures at time 0 for the FG and ABHS groups were 30.8 +/- 15.2 and 77.5 +/- 19.1 mmHg, respectively. At Day 3, the value of ABHS (76.3 +/- 15.8 mmHg) was still significantly higher (P < 0.05) than that of FG (60.0 +/- 21.9 mmHg). At Day 7, no statistical difference was observed between the FG group (71.2 +/- 18.6 mmHg) and the ABHS group (88.8 +/- 11.7 mmHg). Histological examination of the incision at Day 14 revealed that neither sealant was not visible at the incision site, and there was no evidence of adverse tissue reaction. It was concluded that ABHS had good sealing properties and is an alternative to FG for air leakage treatment in pulmonary surgery. (C) 2001 John Wiley & Sons, Inc.