Time dependent efficiency of optical resolution of aminooxiranes with O,O′-dibenzoyl-(R,R)-tartaric acid
Time dependent efficiency of optical resolution of aminooxiranes with O,O′-dibenzoyl-(R,R)-tartaric acid
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DOI：
10.3998/ark.5550190.0005.705
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发表时间：
2004-01-01
期刊：
影响因子：
0.9
通讯作者：
Mordini, A
中科院分区：
文献类型：
--
作者：
Faigl, F;Thurner, A;Mordini, A
研究了两种氨基环氧烷衍生物的结晶时间效应。时间尺度实验表明，拆分剂对氨基环氧乙烷对映体的高效手性识别是在溶液、对映体混合物的沉淀盐和拆分剂之间缓慢的、扩散控制的对映体交换中进行的。对所确定的拆分氨基氧烷的绝对构型的比较表明，结构相似的两种模型化合物的准对映体在相同的拆分剂乙酸乙酯中结晶。
Crystallization time dependent efficiencies of optical resolutions of two aminooxirane derivatives have been investigated. Time-scaled experiments demonstrated that efficient chiral discrimination of aminooxirane enantiomers by the resolving agent develops in slow, diffusion controlled exchange of the enantiomers between the solution and the precipitated salt of an enantiomeric mixture and the resolving agent. Comparison of the determined absolute configurations of the resolved aminooxiranes showed that quasi enantiomers of the structurally similar two model compounds crystallized with the same resolving agent from ethyl acetate.