A 30-year systematic review and meta-analysis of hepatitisB virus among blood donors in mainland China: revealing increase of new threats
A 30-year systematic review and meta-analysis of hepatitisB virus among blood donors in mainland China: revealing increase of new threats
复制标题
中国大陆献血者乙型肝炎病毒30年系统回顾与荟萃分析：揭示新威胁的增加
作者：
Gao Zhan;Zhang Yu;Shan Hua;Shi Ling;Liu Jing;Xu Min;Zeng Peibin;Liu Yu;He Miao
尽管筛查策略已在血液中心常规实施，但输血传播的B型肝炎病毒（HBV）的剩余风险仍构成中国公共卫生问题。本研究的目的是调查HBV血液筛查反应率，并说明了相应的献血者的人口统计学与揭示以前的研究之间的异质性，发现潜在的疏忽threats.Study设计和METHODS文献报道的HBV筛查反应率在中国献血者通过系统搜索四个电子数据库确定。我们遵循系统性综述和Meta-分析项目首选报告指南，并通过Stata 12.0进行数据处理和统计分析。结果显示，合并的献血后筛查反应率为1.32%。（95%置信区间[CI]，1.28%-1.36%），与3.93%有显著差异从1998年前的1.22%（95%CI，3.45%-4.40%）降至1998年《献血法》实施后的1.22%（95%CI，1.18%-1.27%）。重要的是，HBV筛查反应率在替代和计划献血者中显著高于个体自愿献血者。结论我们的结果表明，中国血液中心应招募更多的个体和团体自愿献血者，并将更多符合条件的首次献血者转化为重复献血者，以降低输血传播HBV的风险。
BACKGROUNDAlthough screening strategies have been routinely implemented in blood centers, the residual risk of transfusion‐transmitted hepatitis B virus (HBV) still poses a public health concern in China. The aim of this study is to investigate the HBV blood screening reactive rate and to illustrate the demographics of the corresponding blood donors with revealing of heterogeneity between previous studies and discovering potentially negligent threats.STUDY DESIGN AND METHODSLiterature reporting the HBV screening reactive rate in Chinese blood donors was identified by systematic searching of four electronic databases. We followed the Preferred Reporting of Items for Systematic Reviews and Meta‐Analyses guidelines, and data manipulation and statistical analyses were performed by Stata 12.0.RESULTSOur results showed that the pooled postdonation screening reactive rate was 1.32% (95% confidence interval [CI], 1.28%‐1.36%) with a significant variation from 3.93% (95% CI, 3.45%‐4.40%) before 1998 to 1.22% (95% CI, 1.18%‐1.27%) after 1998 when the Blood Donation Law was implemented. Importantly, the HBV screening reactive rates were significantly higher among replacement and planned donors than among individual voluntary donors.CONCLUSIONOur results indicated blood centers in China should recruit more individual and group voluntary donors and convert more eligible first‐time donors into repeat donors to reduce the risk of transfusion‐transmitted HBV.