The same but different: signaling pathways in control of endothelial cell migration
The same but different: signaling pathways in control of endothelial cell migration
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DOI：
10.1016/j.ceb.2015.07.009
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发表时间：
2015-10-01
影响因子：
7.5
通讯作者：
Siekmann, Arndt F.
中科院分区：
文献类型：
--
作者：
Hasan, Sana S.;Siekmann, Arndt F.
内皮细胞的协调迁移不仅在胚胎血管系统的组装中起着关键作用，而且在组织再生和伤口愈合等各种生理和病理过程中也起着至关重要的作用。最近关于EC在不同血管床中迁移的研究报告揭示了ECs用来确保正确迁移行为的分子的共同原理，但也揭示了惊人的差异。除了遗传因素外，血流动力学因素也会影响EC的迁移，从而促进血管重塑。在这篇综述中，我们将讨论指导EC在不同组织中迁移的不同分子，并强调它们的作用模式。
The coordinated migration of endothelial cells (ECs) plays a pivotal role not only in the assembly of the embryonic vasculature, but also during various physiological and pathological processes, such as tissue regeneration and wound healing. Recent reports studying EC migration in distinct vascular beds have revealed common principles, but also surprising differences, in the molecules ECs use to ensure proper migratory behaviors. In addition to genetic cues, hemodynamic forces in perfused blood vessels also affect EC migration, thereby contributing to blood vessel remodeling. In this review, we will discuss the distinct molecules guiding EC migration in different tissues and highlight their modes of action.