Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective.
Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective.
复制标题
胚胎头部复旧和雄性终生的旋转需要果蝇基因座头部复旧缺陷。
DOI：
10.1093/genetics/129.3.783
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发表时间：
1991
期刊：
影响因子：
3.3
通讯作者：
Lengyel,JA
中科院分区：
文献类型：
--
作者：
Abbott,MK;Lengyel,JA
我们的特点是头部退化缺陷（HID）的基因座，它位于染色体区域75 B8-C1，2。在胚胎头部区域的形态发生重组过程中，Hid+功能对于背侧褶皱穿过前襟和唇腭裂的运动是必要的，这是形成额囊的过程。HID突变体胚胎中额囊的缺失影响背桥的形成并破坏幼虫头咽骨骼的发育。除了其胚胎的作用，这种相同的隐藏功能也需要在蛹的发展为360度旋转的男性终端的前后身体轴，并为后期步骤的翅膀叶片形态。虽然由Wrinkled（W）突变引起的异常翅表型与由失去功能的HID突变引起的翅表型完全不同，但EMS诱导的W回复突变体的表征揭示了W实际上是HID的反形等位基因。
We have characterized the head involution defective (hid) locus which is located within the chromosomal region 75B8-C1,2. During the morphogenetic reorganization of the embryonic head region, hid+ function is necessary for the movement of the dorsal fold across the procephalon and clypeolabrum, a process that forms the frontal sac. The absence of the frontal sac in the hid mutant embryos affects the formation of the dorsal bridge and disrupts the development of the larval cephalopharyngeal skeleton. In addition to its embryonic role, this same hid function is also required during pupal development for the 360 degrees rotation of the male terminalia about the anterior-posterior body axis, and for a late step of wing blade morphogenesis. Although the abnormal wing phenotype caused by the Wrinkled (W) mutation is quite different from the one resulting from the loss-of-function hid mutations, the characterization of EMS-induced W revertants reveals that W is actually an antimorphic allele of hid.