Weaker prepulse exerts stronger suppression of a change-detecting neural circuit
Weaker prepulse exerts stronger suppression of a change-detecting neural circuit
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DOI：
10.1016/j.neures.2020.07.007
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发表时间：
2021-07-31
影响因子：
2.9
通讯作者：
Okada, Motohiro
中科院分区：
文献类型：
--
作者：
Fujii, Shinobu;Motomura, Eishi;Okada, Motohiro
连续声音的声音特征变化后 90-180 ms 的变化 N1 峰值明显被前面的变化刺激（称为 p 间距分音排斥）衰减。在这里，我们研究了先前的声压降低对随后的 Change-N1 振幅的抑制程度的影响。使用 100 Hz 的点击列车声音，我们从 11 名健康志愿者那里获得了 Change-N1。两种类型的测试刺激是从基线 (70 dB) 突然增加 10 dB，以及在声音中间插入 0.45 毫秒的耳间时间差。用作预脉冲的变化开始前 30、40 和 50 毫秒的连续三次点击比背景弱 5 或 10 dB。两个测试刺激引起的 Change-N1 被较弱的前脉冲衰减得更强烈，这与后续感觉/感觉运动处理的抑制取决于前脉冲的声压级的理论不一致。这些结果表明，任何类型的声音特征的变化都会引起与变化相关的响应，该响应会被任何类型的先前变化刺激所抑制，这反映了变化响应电路的自动抑制。 (c) 2020 Elsevier B.V. 和日本神经科学学会。版权所有。
Change-N1 peaking 90-180 ms after changes in a sound feature of a continuous sound is clearly attenuated by a preceding change stimulus (called a p spacing diaeresis repulse) spacing diaeresis . Here, we investigated the effects of a preceding decrease in sound pressure on the degree of inhibition of the subsequent Change-N1 amplitude. Using 100-Hz click train sounds, we obtained Change-N1s from 11 healthy volunteers. The two types of test stimuli were an abrupt 10-dB increase from the baseline (70 dB) and the insertion of a 0.45-ms inter-aural time difference in the middle of the sound. Three consecutive clicks at 30, 40, and 50 ms before the change onset that was used as a prepulse were weaker than the background by 5 or 10 dB. The Change-N1 elicited by the two test stimuli was attenuated more strongly by the weaker prepulse, which was not congruent with the theory that the inhibition of the subsequent sensory/sensory-motor processing depends on the sound pressure level of a prepulse. These results suggest that a change in any type of sound feature elicits a change-related response that is inhibited by any type of preceding change stimulus, which reflects auto-inhibition of the change-responding circuit. (c) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.