BREAST-CANCER IN MOTHERS GIVEN DIETHYLSTILBESTROL IN PREGNANCY
BREAST-CANCER IN MOTHERS GIVEN DIETHYLSTILBESTROL IN PREGNANCY
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DOI：
10.1056/nejm198411293112201
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发表时间：
1984-01-01
影响因子：
158.5
通讯作者：
COLTON, T
中科院分区：
文献类型：
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作者：
GREENBERG, ER;BARNES, AB;COLTON, T
将1940-1960年间3033名孕期服用己烯雌酚(DES)的妇女的乳腺癌发病率与未接触己烯雌酚的可比组产妇的乳腺癌发病率进行比较。95%的暴露妇女和93%的非暴露妇女确定了生命状态，并分别收到了88%和85%的完整问卷。在每组超过85,000名妇女年的随访中，暴露组每100,000妇女年的乳腺癌发病率为134，而非暴露组为93，粗略的相对风险为1.4(95%可信区间，1.1-1.9)。增加的发病率似乎不是由于偏见或研究中测量的其他危险因素的混淆造成的。在暴露的女性中，乳腺癌死亡率略高(相对风险，1.1)，但并不显著(95%可信区间，0.7-2.0)。在服用DES的女性中，乳腺癌的发病率适度增加，但不能排除DES暴露的某些未被识别的伴随因素导致这种增加的可能性。
The incidence of breast cancer in 3033 women who had taken diethylstilbestrol (DES) in pregnancy during the period from 1940-1960 was compared with the incidence in a comparable group of unexposed parous women. Vital status was ascertained in 95% of the exposed women and in 93% of the unexposed women and received completed questionnaires for 88 and 85%, respectively. With over 85,000 woman-yr of follow-up in each group, the incidence of breast cancer per 100,000 woman-yr was 134 in the exposed group and 93 in the unexposed group, yielding a crude relative risk of 1.4 (95% confidence interval, 1.1-1.9). The elevated incidence did not appear to be due to bias or to confounding by other risk factors measured in the study. Breast-cancer mortality was slightly higher in the exposed women (relative risk, 1.1) but not significantly so (95% confidence interval, 0.7-2.0). The incidence of breast cancer is moderatly increased in women given DES, but the possibility that some unrecognized concomitant of DES exposure accounts for this increase cannot be excluded.