Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice
Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice
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DOI：
10.1016/j.bbrc.2008.08.020
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发表时间：
2008-10-24
影响因子：
3.1
通讯作者：
Ishigami, Akihito
中科院分区：
文献类型：
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作者：
Sato, Yasunori;Kajiyama, Shizuo;Ishigami, Akihito
氢是一种公认的抗氧化剂，可防止急性氧化应激。为了阐明氢在脑中的作用机制，我们给衰老标记蛋白30（SMP 30）/β-内酯酶（GNL）敲除（KO）小鼠施用富氢纯水（H（2））。它不能合成维生素C（VC），也是一种众所周知的抗氧化剂。这些KO小鼠被分为三组：接受H（2），VC或纯水（H（2）O），给药33天。H（2）和H（2）O组的VC水平分别为
Hydrogen is an established anti-oxidant that prevents acute oxidative Stress. To Clarify the mechanism of hydrogen's effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice. which cannot synthesize vitamin C (VC) also a well-known anti-oxidant. These KO mice were divided into three groups: recipients of H(2), VC, or pure water (H(2)O), administered for 33 days. VC levels in H(2) and H(2)O groups were