Epidemiology and risk factors of pancreatic cancer.
Epidemiology and risk factors of pancreatic cancer.
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DOI：
10.23750/abm.v89i9-s.7923
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发表时间：
2018-12-17
期刊：
影响因子：
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通讯作者：
Di Mario, Francesco
中科院分区：
文献类型：
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作者：
Capasso, Mario;Franceschi, Marilisa;Di Mario, Francesco
最常见的胰腺癌是胰腺癌。它具有高度和早期的局部和远处侵袭性;这就是为什么它通常在早期阶段表现出很少的体征或症状，并且在诊断后预后差，经常处于晚期阶段。尽管由于其肿瘤前体（PanINs），有可能在早期检测到这种肿瘤。流行病学数据显示，胰腺癌并不常见，但显然它是世界上最常见的肿瘤性死亡原因之一。随着风险因素的增加，发病率呈逐年上升趋势。关于风险因素，在所有情况下都不容易检测到，但已知其中一些的作用：有遗传风险因素，如遗传模式，如HBOC，HNPCC，FAP，PJS，FAMMM，HP和CF以及环境因素（可修改），如吸烟，饮酒，慢性胰腺炎，肥胖和糖尿病。本文对胰腺癌的流行病学资料及相关危险因素进行综述。
The most frequent pancreatic cancer is pancreatic adenocarcinoma. It has high and early locally and distant invasiveness; this is the reason why it often shows little sign or symptoms in early stage and poor prognosis after the diagnosis, frequently in advanced stage. Although it is possible to detect this tumor in early stage because of its neoplastic precursor (PanINs). Epidemiological data shows that pancreatic cancer is not very common but obvious it is one of the most neoplastic death-cause in the world. The trend of incidence is quite increasing through years, proportionally to the increase of risk factors. About risk factors, it is not easy to detect in all the cases but it is known the role of some of that: there are hereditary risk factors, such as genetic pattern like HBOC, HNPCC, FAP, PJS, FAMMM, HP and CF and environmental ones (modifiable) such as smoke, alcohol consumption, chronic pancreatitis, obesity and diabetes mellitus. This narrative review aims to analyze the epidemiological data of pancreatic cancer and associated risk factors.