A Method for Quantification of Stretch Reflex Excitability During Ballistic Reaching.
A Method for Quantification of Stretch Reflex Excitability During Ballistic Reaching.
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DOI：
10.1109/tnsre.2023.3283861
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发表时间：
2023
影响因子：
4.9
通讯作者：
Dewald, Julius P. A.
中科院分区：
文献类型：
--
作者：
Plaisier, Thomas A. M.;Acosta, Ana Maria;Dewald, Julius P. A.
拉伸反射对于执行准确的动作和对不可预测的扰动进行快速校正至关重要。脊髓上结构通过离皮质通路调节牵张反射。这些结构中的神经活动难以直接观察，但意志运动期间反射兴奋性的表征可用于研究这些结构如何调节反射以及神经损伤如何影响这种控制，例如中风后的痉挛。我们已经开发了一种新的协议，以量化牵张反射的兴奋性在弹道达到。这种新方法是使用自定义触觉设备（NACT-3D）实现的，该设备能够在手臂平面中施加高速（270 °/s）关节扰动，同时参与者在大工作空间中执行3D到达任务。我们对四名慢性轻偏瘫中风患者和两名对照组患者进行了评估。参与者达到弹道从近到远的目标，肘部扩展扰动应用在随机捕获试验。在运动之前、运动的早期阶段或接近峰值运动速度时施加扰动。初步结果表明，牵拉反射引起中风组的二头肌在达到，通过肌电图（EMG）活动之前（运动前阶段）和运动过程中（早期运动阶段）。在运动前期，三角肌前部和胸大肌也出现反射性肌电图。在对照组中，如预期的那样，没有观察到反射性EMG。这种新开发的方法允许研究牵张反射调制的新方法相结合的多关节运动与触觉环境和高速扰动。
Stretch reflexes are crucial for performing accurate movements and providing rapid corrections for unpredictable perturbations. Stretch reflexes are modulated by supraspinal structures via corticofugal pathways. Neural activity in these structures is difficult to observe directly, but the characterization of reflex excitability during volitional movement can be used to study how these structures modulate reflexes and how neurological injuries impact this control, such as in spasticity after stroke. We have developed a novel protocol to quantify stretch reflex excitability during ballistic reaching. This novel method was implemented using a custom haptic device (NACT-3D) capable of applying high-velocity (270 °/s) joint perturbations in the plane of the arm while participants performed 3D reaching tasks in a large workspace. We assessed the protocol on four participants with chronic hemiparetic stroke and two control participants. Participants reached ballistically from a near to a far target, with elbow extension perturbations applied in random catch trials. Perturbations were applied before movement, during the early phase of movement, or near peak movement velocity. Preliminary results show that stretch reflexes were elicited in the stroke group in the biceps muscle during reaching, as measured by electromyographic (EMG) activity both before (pre-motion phase) and during (early motion phase) movement. Reflexive EMG was also seen in the anterior deltoid and pectoralis major in the pre-motion phase. In the control group, no reflexive EMG was seen, as expected. This newly developed methodology allows the study of stretch reflex modulation in new ways by combining multijoint movements with haptic environments and high-velocity perturbations.